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Tchem
GPR88
Probable G-protein coupled receptor 88

Protein Summary
Description
Probable G-protein coupled receptor implicated in a large repertoire of behavioral responses that engage motor activities, spatial learning, and emotional processing. May play a role in the regulation of cognitive and motor function. The protein encoded by this gene is a G protein-coupled receptor found almost exclusively in the striatum, a brain structure that controls motor function and cognition. Defects in this gene have been associated with chorea, speech delay, and learning difficulties, as well as some neuropsychiatric disorders. [provided by RefSeq, Mar 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315033
  • ENSP00000314223
  • ENSG00000181656

Symbol
  • STRG
  • STRG
  • COCPMR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.72
tissue sample
0.6
cell type or tissue
0.57
gene perturbation
0.56
tissue
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.86   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 193   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.86   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 193   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 103
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (46)
LRRC39
Tdark
Novelty:  0.70657884
Score:  0.757
Data Source:  STRINGDB
GPR6
Tchem
Family:  GPCR
Novelty:  0.05964344
Score:  0.721
Data Source:  STRINGDB
SLC30A7
Tbio
Family:  Transporter
Novelty:  0.02998245
Score:  0.72
Data Source:  STRINGDB
DPH5
Tbio
Family:  Enzyme
Novelty:  0.09745698
Score:  0.713
Data Source:  STRINGDB
DBT
Tbio
Family:  Enzyme
Novelty:  0.0070589
Score:  0.71
Data Source:  STRINGDB
RTCA
Tbio
Family:  Enzyme
Novelty:  0.03086235
Score:  0.686
Data Source:  STRINGDB
GPR75
Tbio
Family:  GPCR
Novelty:  0.11693296
Score:  0.643
Data Source:  STRINGDB
CDC14A
Tbio
Family:  Enzyme
Novelty:  0.00416647
Score:  0.604
Data Source:  STRINGDB
GPR141
Tdark
Family:  GPCR
Novelty:  0.30711523
Score:  0.603
Data Source:  STRINGDB
GPR52
Tchem
Family:  GPCR
Novelty:  0.07988639
Score:  0.587
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
GPCRs, Other
WikiPathways
GPCRs, Other
WikiPathways
Vitamin D Receptor Pathway
WikiPathways
Major receptors targeted by epinephrine and norepinephrine
Name
Explore in Pharos
Explore in Source
GPCRs, Other
GPCRs, Other
Vitamin D Receptor Pathway
Major receptors targeted by epinephrine and norepinephrine
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
2
2
86.5
monocyte percentage of leukocytes
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
86.5
monocyte percentage of leukocytes
1
17.8
Find similar targets by:
IDG Resources
Genetic Construct
GPR88-Tango
image for GPR88-Tango
Details:
  • Vector:  addgene66380
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  FLAG
Data:
  • GPR88-Tango
Order Genetic Construct from:
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 88
VGNC:11444
735527
Mouse
MGI:1927653
64378
Rat
RGD:61921
64443
Dog
G protein-coupled receptor 88
VGNC:54029
100686636
Cow
G protein-coupled receptor 88
VGNC:29604
781302
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 88
Mouse
Rat
Dog
G protein-coupled receptor 88
Cow
G protein-coupled receptor 88
Publication Statistics
PubMed Score 48.86
PubMed score by year
PubTator Score 13.18
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title