GPR88
Probable G-protein coupled receptor 88
Protein Summary
Probable G-protein coupled receptor implicated in a large repertoire of behavioral responses that engage motor activities, spatial learning, and emotional processing. May play a role in the regulation of cognitive and motor function. The protein encoded by this gene is a G protein-coupled receptor found almost exclusively in the striatum, a brain structure that controls motor function and cognition. Defects in this gene have been associated with chorea, speech delay, and learning difficulties, as well as some neuropsychiatric disorders. [provided by RefSeq, Mar 2017]
- ENST00000315033
- ENSP00000314223
- ENSG00000181656
- STRG
- STRG
- COCPMR
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
microRNA | 0.72 | ||
tissue sample | 0.6 | ||
cell type or tissue | 0.57 | ||
gene perturbation | 0.56 | ||
tissue | 0.54 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 48.86 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 193 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 48.86 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 193 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 103
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (103)
Protein-Protein Interactions (46)
Nearest Tclin Targets
Pathways (4)
WikiPathways (4)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
WikiPathways | GPCRs, Other | ||||
WikiPathways | GPCRs, Other | ||||
WikiPathways | Vitamin D Receptor Pathway | ||||
WikiPathways | Major receptors targeted by epinephrine and norepinephrine | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
GPCRs, Other | ||||
GPCRs, Other | ||||
Vitamin D Receptor Pathway | ||||
Major receptors targeted by epinephrine and norepinephrine | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (2)
Components (4)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
monocyte count | 2 | 2 | 2 | 86.5 | |||||
monocyte percentage of leukocytes | 1 | 1 | 1 | 17.8 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
monocyte count | 2 | 86.5 | |||||
monocyte percentage of leukocytes | 1 | 17.8 | |||||
Find similar targets by:
IDG Resources
Reagents (1)
Genetic Construct
GPR88-Tango
Details:
- Vector: addgene66380
- Vector backbone: pcDNA3.1(+)
- Promoter: CMV
- Tag: FLAG
Data:
- GPR88-Tango
Order Genetic Construct from:
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | G protein-coupled receptor 88 | VGNC:11444 | 735527 | |||||
Mouse | MGI:1927653 | 64378 | ||||||
Rat | RGD:61921 | 64443 | ||||||
Dog | G protein-coupled receptor 88 | VGNC:54029 | 100686636 | |||||
Cow | G protein-coupled receptor 88 | VGNC:29604 | 781302 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | G protein-coupled receptor 88 | |||||
Mouse | ||||||
Rat | ||||||
Dog | G protein-coupled receptor 88 | |||||
Cow | G protein-coupled receptor 88 | |||||
Publication Statistics
PubMed Score 48.86
PubMed score by year
PubTator Score 13.18
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (8)
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Year | Title |
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