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Tbio
TINAGL1
Tubulointerstitial nephritis antigen-like

Protein Summary
Description
May be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells. This is a non catalytic peptidase C1 family protein (By similarity). The protein encoded by this gene is similar in sequence to tubulointerstitial nephritis antigen, a secreted glycoprotein that is recognized by antibodies in some types of immune-related tubulointerstitial nephritis. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000271064
  • ENSP00000271064
  • ENSG00000142910
  • ENST00000457433
  • ENSP00000395137

Symbol
  • GIS5
  • LCN7
  • OLRG2
  • TINAGL
  • ARG1
  • LCN7
  • LIECG3
  • TINAGRP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
virus
0.89
viral protein
0.8
transcription factor
0.77
small molecule perturbation
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.51   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 177   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.51   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (45)
1 – 10 of 45
HSPG2
Tbio
Family:  Enzyme
Novelty:  0.00159541
p_int:  0.999999762
p_ni:  1.2e-8
p_wrong:  2.25e-7
Score:  0.591
Data Source:  BioPlex,STRINGDB
RIOK1
Tchem
Family:  Kinase
Novelty:  0.02476698
p_int:  0.999879025
p_ni:  0.000120975
Score:  0.198
Data Source:  BioPlex,STRINGDB
PRMT5
Tchem
Family:  Epigenetic
Novelty:  0.00395474
p_int:  0.977628696
p_ni:  0.022371304
Score:  0.28
Data Source:  BioPlex,STRINGDB
CD59
Tbio
Novelty:  0.0008352
p_int:  0.955720646
p_ni:  0.003331773
p_wrong:  0.04094758
Score:  0.545
Data Source:  BioPlex,STRINGDB
LOXL2
Tchem
Family:  Enzyme
Novelty:  0.00599536
p_int:  0.869958755
p_ni:  0.014962487
p_wrong:  0.115078757
Score:  0.388
Data Source:  BioPlex,STRINGDB
GNB2
Tbio
Novelty:  0.08682553
p_int:  0.863357279
p_ni:  0.136642668
p_wrong:  5.3e-8
Data Source:  BioPlex
TMEM59
Tbio
Novelty:  0.0329414
Score:  0.692
Data Source:  STRINGDB
CAVIN2
Tbio
Novelty:  0.00979388
Score:  0.664
Data Source:  STRINGDB
ICK
Tchem
Family:  Kinase
Novelty:  0.00810476
Score:  0.65
Data Source:  STRINGDB
SEC23A
Tbio
Novelty:  0.0384262
Score:  0.641
Data Source:  STRINGDB
Gene Ontology Terms (13)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
5
15
7
5.8
84.4
cognitive function measurement
3
2
3
68.5
self reported educational attainment
2
2
1
6.1
68.1
body mass index
1
1
1
36.5
daytime rest measurement
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
7
5.8
84.4
cognitive function measurement
3
68.5
self reported educational attainment
1
6.1
68.1
body mass index
1
36.5
daytime rest measurement
1
24.5
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tubulointerstitial nephritis antigen like 1
VGNC:8553
469260
Macaque
tubulointerstitial nephritis antigen like 1
705660
Mouse
MGI:2137617
94242
Rat
RGD:70956
94174
Dog
tubulointerstitial nephritis antigen like 1
VGNC:47380
478155
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tubulointerstitial nephritis antigen like 1
Macaque
tubulointerstitial nephritis antigen like 1
Mouse
Rat
Dog
tubulointerstitial nephritis antigen like 1
Publication Statistics
PubMed Score 23.51
PubMed score by year
PubTator Score 6.34
PubTator score by year