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Tbio
WDR12
Ribosome biogenesis protein WDR12

Protein Summary
Description
Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein is highly similar to the mouse WD repeat domain 12 protein at the amino acid level. The protein encoded by this gene is a component of a nucleolar protein complex that affects maturation of the large ribosomal subunit.[provided by RefSeq, Dec 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261015
  • ENSP00000261015
  • ENSG00000138442

Symbol
  • YTM1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
hub protein
0.85
histone modification site profile
0.84
disease perturbation
0.83
kinase perturbation
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.71   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.71   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
5
2
1.1
95.5
2
2
0
1.1
55.4
1
1
0
1.2
45.4
white matter hyperintensity measurement
1
1
1
29
low density lipoprotein cholesterol measurement
1
1
1
24.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.1
95.5
0
1.1
55.4
0
1.2
45.4
white matter hyperintensity measurement
1
29
low density lipoprotein cholesterol measurement
1
24.7
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 12
VGNC:3874
459888
Mouse
MGI:1927241
57750
Rat
RGD:735072
363237
Dog
WD repeat domain 12
VGNC:48351
478876
Horse
WD repeat domain 12
VGNC:24982
100067464
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 12
Mouse
Rat
Dog
WD repeat domain 12
Horse
WD repeat domain 12
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9GZL7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA processing
rRNA processing in the nucleus and cytosol
Gene Ontology Terms (11)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Protein-Protein Interactions (478)
1 – 10 of 478
PES1
Tbio
Novelty: 0.07162845
p_int: 0.999989028
p_ni: 0.000010972
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
CASQ2
Tbio
Novelty: 0.00775794
p_int: 0.922275502
p_ni: 0.077724498
Score: 0.51
Data Source: BioPlex,STRINGDB
WDR55
Tdark
Novelty: 0.51900003
p_int: 0.89894471
p_ni: 0.10105529
Score: 0.954
Data Source: BioPlex,STRINGDB
NIFK
Tbio
Novelty: 0.01221562
p_int: 0.831065792
p_ni: 0.168934208
Score: 0.991
Data Source: BioPlex,STRINGDB
IGHMBP2
Tbio
Novelty: 0.01054517
p_int: 0.83052958
p_ni: 0.16947042
Score: 0.269
Data Source: BioPlex,STRINGDB
DGCR8
Tbio
Novelty: 0.00271221
p_int: 0.779945219
p_ni: 0.220054781
Data Source: BioPlex
BOP1
Tbio
Novelty: 0.03512044
Score: 0.999
Data Source: Reactome,STRINGDB
EBNA1BP2
Tbio
Novelty: 0.02083466
Score: 0.999
Data Source: STRINGDB
BRIX1
Tbio
Novelty: 0.16561444
Score: 0.997
Data Source: STRINGDB
NOP58
Tbio
Novelty: 0.02148045
Score: 0.997
Data Source: STRINGDB
Publication Statistics
PubMed Score  31.71

PubMed score by year
PubTator Score  9.93

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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