Tdark OR2H1 Olfactory receptor 2H1

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Olfactory Receptor / Olfactory Receptor 2H1

Protein Summary

Description

Odorant receptor. Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9GZK4
• B0S7T4
• O43629
• O43661
• O43662
• Q5SUN6
• Q9GZK9

Gene Name

• OR2H1

Ensembl ID

• ENST00000377132
• ENSP00000366336
• ENSG00000204688
• ENST00000377133
• ENSP00000366337
• ENST00000377136
• ENSP00000366340
• ENST00000383550
• ENSP00000373042
• ENSG00000206471
• ENST00000383644
• ENSP00000373140
• ENSG00000206516
• ENST00000396792
• ENSP00000380010
• ENST00000400689
• ENSP00000383527
• ENST00000400693
• ENSP00000383529
• ENST00000400694
• ENSP00000383530
• ENST00000400712
• ENSP00000383547
• ENST00000400713
• ENSP00000383548
• ENST00000400714
• ENSP00000383549
• ENST00000412956
• ENSP00000407739
• ENSG00000232984
• ENST00000415581
• ENSP00000396944
• ENSG00000224395
• ENST00000416582
• ENSP00000395850
• ENSG00000229125
• ENST00000418376
• ENSP00000395567
• ENSG00000229408
• ENST00000421808
• ENSP00000410401
• ENST00000431658
• ENSP00000394698
• ENST00000435958
• ENSP00000397171
• ENST00000436167
• ENSP00000388844
• ENSG00000235132
• ENST00000438840
• ENSP00000412463
• ENST00000439879
• ENSP00000409651
• ENST00000440557
• ENSP00000413910
• ENST00000440672
• ENSP00000396414
• ENST00000443407
• ENSP00000398695
• ENST00000444920
• ENSP00000410659
• ENST00000446161
• ENSP00000389230
• ENST00000449826
• ENSP00000411617
• ENST00000453467
• ENSP00000392619
• ENST00000454071
• ENSP00000395934
• ENST00000456657
• ENSP00000408584
• ENST00000458051
• ENSP00000405714

Symbol

• OR2H6
• OR2H8
• OR2H6
• OR2H8
• OR6-2
• 6M1-16
• HS6M1-16
• dJ994E9.4
• OLFR42A-9004-14
• OLFR42A-9004.14/9026.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.88
microRNA	0.57
cell line	0.51
disease	0.46
virus perturbation	0.45

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.59   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 64   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.59   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (1)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
glomerular filtration rate	EFO_0005208	1	1	1		2.8

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
glomerular filtration rate	EFO_0005208	1		2.8

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Orthologs (3)

1 – 3 of 3

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	olfactory receptor 93	MGI:2177476	258051
Horse	olfactory receptor 2H1-like		100056985
Cow	olfactory receptor 2H1		506486

Species	Name	OMA	EggNOG	Inparanoid
Mouse	olfactory receptor 93
Horse	olfactory receptor 2H1-like
Cow	olfactory receptor 2H1

Protein Structure (0 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q9GZK4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)

Reactome (5)

KEGG (1)

WikiPathways (4)

G alpha (s) signalling events (R-HSA-418555)

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Find Similar Targets

Items per page:

5

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	G alpha (s) signalling events	577 targets	R-HSA-418555
Reactome	GPCR downstream signalling	1152 targets	R-HSA-388396
Reactome	Olfactory Signaling Pathway	431 targets	R-HSA-381753
Reactome	Signal Transduction	2704 targets	R-HSA-162582
Reactome	Signaling by GPCR	1212 targets	R-HSA-372790

Name	Explore in Pharos	Explore in Source
G alpha (s) signalling events	577 targets	R-HSA-418555
GPCR downstream signalling	1152 targets	R-HSA-388396
Olfactory Signaling Pathway	431 targets	R-HSA-381753
Signal Transduction	2704 targets	R-HSA-162582
Signaling by GPCR	1212 targets	R-HSA-372790

Gene Ontology Terms (4)

Functions (2)

Components (2)

Find Similar Targets

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
olfactory receptor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
G protein-coupled receptor activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (27)

Explore Interacting Targets

1 – 10 of 27

• See Interactions on String-DB

RTP1

Tbio

Novelty: 0.0278378

Score: 0.921

Data Source: STRINGDB

RTP2

Tbio

Novelty: 0.05972678

Score: 0.918

Data Source: STRINGDB

GNAL

Tbio

Novelty: 0.01757098

Score: 0.911

Data Source: STRINGDB

REEP1

Tbio

Novelty: 0.02280713

Score: 0.907

Data Source: STRINGDB

GNGT1

Tbio

Novelty: 0.05291961

Score: 0.9

Data Source: STRINGDB

RTP4

Tbio

Novelty: 0.05959975

Score: 0.9

Data Source: STRINGDB

REEP6

Tbio

Novelty: 0.10645981

Score: 0.9

Data Source: STRINGDB

RTP5

Tdark

Novelty: 0.21798595

Score: 0.9

Data Source: STRINGDB

REEP4

Tbio

Novelty: 0.37950931

Score: 0.9

Data Source: STRINGDB

REEP5

Tbio

Novelty: 0.00160455

Score: 0.9

Data Source: STRINGDB

Publication Statistics

PubMed Score  2.59

PubMed score by year

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PubTator Score  50.61

PubTator score by year

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Patents

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Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

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UniProt Keyword Find Similar Targets

Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Olfaction
Polymorphism
Receptor
Reference proteome

GWAS Trait Find Similar Targets

glomerular filtration rate