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Tbio
SLC39A8
Zinc transporter ZIP8

Protein Summary
Description
Acts as a manganese and zinc influx transporter (PubMed:12504855, PubMed:26637978). Plays a role in manganese reabsorption in the proximal tubule of the kidney and in manganese uptake into the brain (PubMed:26637978). This gene encodes a member of the SLC39 family of solute-carrier genes, which show structural characteristics of zinc transporters. The encoded protein is glycosylated and found in the plasma membrane and mitochondria, and functions in the cellular import of zinc at the onset of inflammation. It is also thought to be the primary transporter of the toxic cation cadmium, which is found in cigarette smoke. Multiple transcript variants encoding different isoforms have been found for this gene. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356736
  • ENSP00000349174
  • ENSG00000138821
  • ENST00000394833
  • ENSP00000378310
  • ENST00000424970
  • ENSP00000394548

Symbol
  • BIGM103
  • ZIP8
  • ZIP8
  • CDG2N
  • PP3105
  • BIGM103
  • LZT-Hs6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.97
trait
0.93
gene perturbation
0.89
transcription factor binding site profile
0.87
histone modification site profile
0.81


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122.96   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122.96   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (50)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
9
2
8
5.8
99
intelligence
3
5
3
6.1
98.6
alcohol use disorder measurement
5
2
1
7.6
98.5
body mass index
12
1
19
97.7
neuroimaging measurement
1
1
4
97.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
8
5.8
99
intelligence
3
6.1
98.6
alcohol use disorder measurement
1
7.6
98.5
body mass index
19
97.7
neuroimaging measurement
4
97.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 39 member 8
VGNC:7721
461405
Macaque
solute carrier family 39 member 8
710142
Mouse
MGI:1914797
67547
Rat
RGD:1308236
295455
Dog
solute carrier family 39 member 8
VGNC:46407
478494
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 39 member 8
Macaque
solute carrier family 39 member 8
Mouse
Rat
Dog
solute carrier family 39 member 8
Pathways (11)
Metal ion SLC transporters (R-HSA-425410)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metal ion SLC transporters
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of bile salts and organic acids, metal ions and amine compounds
Reactome
Transport of small molecules
Reactome
Zinc influx into cells by the SLC39 gene family
Name
Explore in Pharos
Explore in Source
Metal ion SLC transporters
SLC-mediated transmembrane transport
Transport of bile salts and organic acids, metal ions and amine compounds
Transport of small molecules
Zinc influx into cells by the SLC39 gene family
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (113)
1 – 10 of 113
TAOK2
Tchem
Family: Kinase
Novelty: 0.0232708
p_int: 0.999992227
p_ni: 0.000007773
Data Source: BioPlex
GPD2
Tbio
Family: Enzyme
Novelty: 0.00951917
p_int: 0.999583437
p_ni: 0.000416563
Data Source: BioPlex
RMDN2
Tbio
Novelty: 0.10425524
p_int: 0.997929978
p_ni: 0.000077127
p_wrong: 0.001992895
Score: 0.541
Data Source: BioPlex,STRINGDB
SLC9A6
Tbio
Family: Transporter
Novelty: 0.01410234
p_int: 0.992984258
p_ni: 0.006606873
p_wrong: 0.00040887
Score: 0.171
Data Source: BioPlex,STRINGDB
LEMD2
Tbio
Novelty: 0.12460123
p_int: 0.986237102
p_ni: 0.013762898
Data Source: BioPlex
C1GALT1C1
Tbio
Family: Enzyme
Novelty: 0.01318017
p_int: 0.984693758
p_ni: 0.015301277
p_wrong: 0.000004965
Score: 0.183
Data Source: BioPlex,STRINGDB
C1orf43
Tbio
Novelty: 0.13587458
p_int: 0.983952919
p_ni: 0.013749877
p_wrong: 0.002297205
Data Source: BioPlex
ERGIC2
Tbio
Novelty: 0.08610944
p_int: 0.98200704
p_ni: 0.017992951
p_wrong: 9e-9
Score: 0.179
Data Source: BioPlex,STRINGDB
ZDHHC17
Tbio
Family: Enzyme
Novelty: 0.03288707
p_int: 0.971206768
p_ni: 0.028793191
p_wrong: 4.1e-8
Score: 0.3
Data Source: BioPlex,STRINGDB
EXTL2
Tbio
Family: Enzyme
Novelty: 0.05051027
p_int: 0.970297066
p_ni: 0.0264587
p_wrong: 0.003244233
Score: 0.154
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  122.96

PubMed score by year
PubTator Score  43.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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