Tbio WDR33 pre-mRNA 3' end processing protein WDR33

Protein Summary

Description

Essential for both cleavage and polyadenylation of pre-mRNA 3' ends. This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is highly expressed in testis and the protein is localized to the nucleus. This gene may play important roles in the mechanisms of cytodifferentiation and/or DNA recombination. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9C0J8
• Q05DP8
• Q53FG9
• Q587J1
• Q69YF7
• Q6NUQ0
• Q9NUL1

Gene Name

• WDR33

Ensembl ID

• ENST00000322313
• ENSP00000325377
• ENSG00000136709
• ENST00000393006
• ENSP00000376730
• ENST00000409658
• ENSP00000387186

Symbol

• WDC146
• NET14
• WDC146

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.99
microRNA	0.9
histone modification site profile	0.86
kinase perturbation	0.84
interacting protein	0.79

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Pre-mrna 3' End Processing Protein Wdr33

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Pre-mrna 3' End Processing Protein Wdr33

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.91   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 90   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.91   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0