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Tbio
WDR33
pre-mRNA 3' end processing protein WDR33

Protein Summary
Description
Essential for both cleavage and polyadenylation of pre-mRNA 3' ends. This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is highly expressed in testis and the protein is localized to the nucleus. This gene may play important roles in the mechanisms of cytodifferentiation and/or DNA recombination. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322313
  • ENSP00000325377
  • ENSG00000136709
  • ENST00000393006
  • ENSP00000376730
  • ENST00000409658
  • ENSP00000387186

Symbol
  • WDC146
  • NET14
  • WDC146
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
microRNA
0.9
histone modification site profile
0.86
kinase perturbation
0.84
interacting protein
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.42   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 90   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.42   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
1
1
1
10.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
1
10.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 33
VGNC:3875
470527
Macaque
WD repeat domain 33
699696
Mouse
MGI:1921570
74320
Rat
RGD:1309230
307524
Dog
WD repeat domain 33
VGNC:48360
100856093
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 33
Macaque
WD repeat domain 33
Mouse
Rat
Dog
WD repeat domain 33
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9C0J8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (14)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
Processing of Capped Intronless Pre-mRNA
Reactome
Processing of Intronless Pre-mRNAs
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
Processing of Capped Intronless Pre-mRNA
Processing of Intronless Pre-mRNAs
Gene Ontology Terms (13)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (279)
1 – 10 of 279
P4HA1
Tchem
Family: Enzyme
Novelty: 0.01624726
p_int: 0.999999953
p_ni: 4.7e-8
Score: 0.231
Data Source: BioPlex,STRINGDB
CPSF4
Tbio
Novelty: 0.00206207
p_int: 0.999999918
p_ni: 7.9e-8
p_wrong: 3e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
CPSF2
Tbio
Novelty: 0.0510853
p_int: 0.999998369
p_ni: 0.000001631
Score: 0.999
Data Source: BioPlex,STRINGDB
P4HA2
Tbio
Family: Enzyme
Novelty: 0.02097718
p_int: 0.999992585
p_ni: 0.000007415
Score: 0.172
Data Source: BioPlex,STRINGDB
CPSF4L
Tdark
Novelty: 4.27116708
p_int: 0.999963858
p_ni: 0.000036142
Score: 0.858
Data Source: BioPlex,STRINGDB
P4HA3
Tbio
Family: Enzyme
Novelty: 0.03832564
p_int: 0.999443209
p_ni: 0.000556791
Data Source: BioPlex
JMJD6
Tbio
Family: Enzyme
Novelty: 0.00305479
p_int: 0.997367484
p_ni: 0.002632516
Score: 0.153
Data Source: BioPlex,STRINGDB
VTN
Tbio
Family: TF
Novelty: 0.00046861
p_int: 0.992918629
p_ni: 0.007081371
Data Source: BioPlex
ZC3H18
Tdark
Novelty: 0.3515546
p_int: 0.992129633
p_ni: 0.007870366
p_wrong: 1e-9
Data Source: BioPlex
AHCYL1
Tchem
Family: Enzyme
Novelty: 0.02176432
p_int: 0.990415549
p_ni: 0.009584451
Data Source: BioPlex
Publication Statistics
PubMed Score  11.42

PubMed score by year
PubTator Score  3.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer