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Tdark
DNAH6
Dynein heavy chain 6, axonemal

Protein Summary
Description
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity). This gene belongs to the dynein family, whose members encode large proteins that are constituents of the microtubule-associated motor protein complex. This complex is composed of dynein heavy, intermediate and light chains, which can be axonemal or cytoplasmic. This protein is an axonemal dynein heavy chain. It is involved in producing force for ciliary beating by using energy from ATP hydrolysis. Mutations in this gene may cause primary ciliary dyskinesia (PCD) as well as heterotaxy. [provided by RefSeq, Jun 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000237449
  • ENSP00000237449
  • ENSG00000115423
  • ENST00000389394
  • ENSP00000374045

Symbol
  • DNAHC6
  • DNHL1
  • HL2
  • KIAA1697
  • HL2
  • HL-2
  • DNHL1
  • Dnahc6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
molecular function
0.93
gene perturbation
0.86
trait
0.86
histone modification site profile
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.85   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 27   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.85   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 27   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.3
40.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
40.1
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dynein axonemal heavy chain 6
VGNC:218
459354
Macaque
dynein axonemal heavy chain 6
694115
Mouse
MGI:107744
330355
Rat
RGD:621797
117250
Dog
dynein axonemal heavy chain 6
VGNC:40017
475774
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dynein axonemal heavy chain 6
Macaque
dynein axonemal heavy chain 6
Mouse
Rat
Dog
dynein axonemal heavy chain 6
Protein Structure (0 Structures, 15 AlphaFold Models)
RepresentationColor Scheme

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (10)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (89)
1 – 10 of 89
DNAH12
Tbio
Novelty: 0.02743114
Score: 0.954
Data Source: STRINGDB
DCTN2
Tbio
Novelty: 0.01045432
Score: 0.947
Data Source: STRINGDB
PAFAH1B1
Tbio
Family: Enzyme
Novelty: 0.00256206
Score: 0.942
Data Source: STRINGDB
DCTN1
Tbio
Novelty: 0.00494896
Score: 0.938
Data Source: STRINGDB
CLIP1
Tbio
Novelty: 0.00399891
Score: 0.935
Data Source: STRINGDB
DNAH5
Tbio
Novelty: 0.01579144
Score: 0.924
Data Source: STRINGDB
DNAH8
Tbio
Novelty: 0.10883442
Score: 0.916
Data Source: STRINGDB
DNAH1
Tbio
Novelty: 0.0369386
Score: 0.915
Data Source: STRINGDB
DNAH3
Tdark
Novelty: 0.0628368
Score: 0.912
Data Source: STRINGDB
DCTN3
Tbio
Novelty: 0.14551388
Score: 0.901
Data Source: STRINGDB
Publication Statistics
PubMed Score  5.85

PubMed score by year
PubTator Score  3.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer