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Tbio
ZNF436
Zinc finger protein 436

Protein Summary
Description
May be a transcriptional repressor.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314011
  • ENSP00000313582
  • ENSG00000125945
  • ENST00000374608
  • ENSP00000363736
  • ENST00000635349
  • ENSP00000489127
  • ENSG00000283009
  • ENST00000635400
  • ENSP00000489469

Symbol
  • KIAA1710
  • ZNF
  • Zfp46
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.86
histone modification site profile
0.82
transcription factor
0.73
microRNA
0.65
protein domain
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.93   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.93   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
32.9
heel bone mineral density
1
1
1
32.9
glomerular filtration rate
1
1
1
29.4
glomerular filtration rate
1
1
1
29.4
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
32.9
heel bone mineral density
1
32.9
glomerular filtration rate
1
29.4
glomerular filtration rate
1
29.4
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
zinc finger protein 436
709638
Mouse
MGI:99192
22704
Rat
RGD:1310584
298558
Dog
zinc finger protein 436
VGNC:48727
100684593
Horse
zinc finger protein 436
VGNC:25323
100057918
Species
Name
OMA
EggNOG
Inparanoid
Macaque
zinc finger protein 436
Mouse
Rat
Dog
zinc finger protein 436
Horse
zinc finger protein 436
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9C0F3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Protein-Protein Interactions (38)
1 – 10 of 38
PNLIPRP2
Tbio
Family: Enzyme
p_int: 0.937921151
p_ni: 0.061921428
p_wrong: 0.000157421
Data Source: BioPlex
ECT2L
Tdark
Novelty: 1.21721601
p_int: 0.887574367
p_ni: 0.005288437
p_wrong: 0.107137195
Data Source: BioPlex
TRIM28
Tbio
Family: Epigenetic
Novelty: 0.00778381
Score: 0.956
Data Source: STRINGDB
OTUD7A
Tbio
Novelty: 0.09531354
Score: 0.719
Data Source: STRINGDB
YOD1
Tbio
Family: Enzyme
Novelty: 0.05709057
Score: 0.718
Data Source: STRINGDB
USP44
Tbio
Family: Enzyme
Novelty: 0.0550805
Score: 0.716
Data Source: STRINGDB
USP5
Tchem
Family: Enzyme
Novelty: 0.01478795
Score: 0.653
Data Source: STRINGDB
TMEM184B
Tdark
Novelty: 0.35340207
Score: 0.652
Data Source: STRINGDB
ADAMTSL5
Tbio
Novelty: 0.15248206
Score: 0.642
Data Source: STRINGDB
DOK4
Tbio
Novelty: 0.06349482
Score: 0.608
Data Source: STRINGDB
Publication Statistics
PubMed Score  91.93

PubMed score by year
PubTator Score  4.61

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer