Tbio LNPK Endoplasmic reticulum junction formation protein lunapark

Protein Summary

Description

Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology. Involved in the stabilization of nascent three-way ER tubular junctions within the ER network (PubMed:24223779, PubMed:25404289, PubMed:25548161, PubMed:27619977). May also play a role as a curvature-stabilizing protein within the three-way ER tubular junction network (PubMed:25404289). May be involved in limb and central nervous system development (By similarity).

Uniprot Accession IDs

• Q9C0E8
• B7ZLA8
• Q2M2V8
• Q2YD99
• Q658W8
• Q8N5V9
• Q96MS5

Gene Name

• LNPK

Ensembl ID

• ENST00000272748
• ENSP00000272748
• ENSG00000144320
• ENST00000409660
• ENSP00000386237
• ENST00000544803
• ENSP00000440905

Symbol

• KIAA1715
• LNP
• Ul
• LNP
• LNP1
• NEDEHCC
• KIAA1715
• ulnaless

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.51   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 14   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.51   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 14   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0