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Tdark
GRIP2
Glutamate receptor-interacting protein 2

Protein Summary
Description
May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000621039
  • ENSP00000478352
  • ENSG00000144596

Symbol
  • KIAA1719
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
cell type or tissue
0.84
tissue sample
0.64
small molecule perturbation
0.61
microRNA
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.34   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.34   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (13)
Glutamate binding, activation of AMPA receptors and synaptic plasticity (R-HSA-399721)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glutamate binding, activation of AMPA receptors and synaptic plasticity
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Reactome
Trafficking of AMPA receptors
Reactome
Trafficking of GluR2-containing AMPA receptors
Name
Explore in Pharos
Explore in Source
Glutamate binding, activation of AMPA receptors and synaptic plasticity
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Trafficking of AMPA receptors
Trafficking of GluR2-containing AMPA receptors
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (51)
1 – 10 of 51
GRIA2
Tclin
Family: IC
Novelty: 0.00141257
Score: 0.975
Data Source: Reactome,STRINGDB
PICK1
Tbio
Novelty: 0.0058265
Score: 0.974
Data Source: Reactome,STRINGDB
GRIA3
Tclin
Family: IC
Novelty: 0.00584546
Score: 0.962
Data Source: Reactome,STRINGDB
GRIA1
Tclin
Family: IC
Novelty: 0.0005008
Score: 0.95
Data Source: Reactome,STRINGDB
GRIA4
Tclin
Family: IC
Novelty: 0.00284417
Score: 0.945
Data Source: Reactome,STRINGDB
GRIP1
Tbio
Novelty: 0.00343871
Score: 0.925
Data Source: STRINGDB
PRKCG
Tchem
Family: Kinase
Novelty: 0.00291817
Score: 0.912
Data Source: STRINGDB
NSF
Tbio
Family: Enzyme
Novelty: 0.00173489
Score: 0.912
Data Source: STRINGDB
PRKCA
Tchem
Family: Kinase
Novelty: 0.00057611
Score: 0.909
Data Source: STRINGDB
PRKCB
Tchem
Family: Kinase
Novelty: 0.00189802
Score: 0.909
Data Source: STRINGDB
Publication Statistics
PubMed Score  13.34

PubMed score by year
PubTator Score  11

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer