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Tdark
ZC3H12C
Probable ribonuclease ZC3H12C

Protein Summary
Description
May function as RNase and regulate the levels of target RNA species.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278590
  • ENSP00000278590
  • ENSG00000149289
  • ENST00000528673
  • ENSP00000431821

Symbol
  • KIAA1726
  • MCPIP3
  • MCPIP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
microRNA
0.85
tissue sample
0.78
transcription factor perturbation
0.74
histone modification site profile
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.57   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 50   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.57   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 50   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
5
4
5
78.6
apolipoprotein A 1 measurement
1
1
1
68.6
1
1
0
1.1
40.7
1
1
0
1.1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
5
78.6
apolipoprotein A 1 measurement
1
68.6
0
1.1
40.7
0
1.1
40.7
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:3026959
244871
Rat
RGD:1565078
315658
Dog
zinc finger CCCH-type containing 12C
VGNC:48553
489416
Horse
zinc finger CCCH-type containing 12C [Source:HGNC Symbol;Acc:HGNC:29362]
Cow
zinc finger CCCH-type containing 12C
VGNC:37099
512586
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
zinc finger CCCH-type containing 12C
Horse
zinc finger CCCH-type containing 12C [Source:HGNC Symbol;Acc:HGNC:29362]
Cow
zinc finger CCCH-type containing 12C
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9C0D7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (2)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (31)
1 – 10 of 31
KBTBD3
Tdark
Novelty:  1.73793103
Score:  0.763
Data Source:  STRINGDB
MYO3B
Tchem
Family:  Kinase
Novelty:  0.1365033
Score:  0.713
Data Source:  STRINGDB
JPH1
Tbio
Novelty:  0.00931679
Score:  0.688
Data Source:  STRINGDB
SLC2A9
Tbio
Family:  Transporter
Novelty:  0.00683926
Score:  0.672
Data Source:  STRINGDB
CHMP2A
Tbio
Novelty:  0.00169253
Score:  0.661
Data Source:  STRINGDB
NLN
Tbio
Family:  Enzyme
Novelty:  0.01217367
Score:  0.58
Data Source:  STRINGDB
PIK3CB
Tchem
Family:  Kinase
Novelty:  0.00390277
Score:  0.572
Data Source:  STRINGDB
ZC3HAV1L
Tdark
Novelty:  1.84562875
Score:  0.567
Data Source:  STRINGDB
ZC3H15
Tbio
Novelty:  0.15630592
Score:  0.556
Data Source:  STRINGDB
NEDD8
Tchem
Novelty:  0.00305343
Score:  0.551
Data Source:  STRINGDB
Publication Statistics
PubMed Score  3.57

PubMed score by year
PubTator Score  2.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer