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Tdark
TANC1
Protein TANC1

Protein Summary
Description
May be a scaffold component in the postsynaptic density.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263635
  • ENSP00000263635
  • ENSG00000115183

Symbol
  • KIAA1728
  • TANC
  • ROLSB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
trait
0.97
protein domain
0.92
protein complex
0.87
microRNA
0.82


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.2   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 40   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.2   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 40   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
4
5
95.1
mean corpuscular volume
1
1
1
67.8
red blood cell distribution width
2
2
2
56.4
response to radiation
1
1
1
46.9
reticulocyte count
1
1
1
27.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
5
95.1
mean corpuscular volume
1
67.8
red blood cell distribution width
2
56.4
response to radiation
1
46.9
reticulocyte count
1
27.3
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
VGNC:2876
459678
Macaque
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
699196
Mouse
MGI:1914110
66860
Rat
RGD:1302949
311055
Dog
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
VGNC:47098
478760
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
Macaque
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
Mouse
Rat
Dog
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9C0D5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (9)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (52)
1 – 10 of 52
TAX1BP3
Tbio
Novelty:  0.01605171
p_int:  0.999999961
p_ni:  3.9e-8
Data Source:  BioPlex
DLG1
Tbio
Novelty:  0.0050926
Score:  0.946
Data Source:  STRINGDB
DLG4
Tchem
Novelty:  0.00057285
Score:  0.93
Data Source:  STRINGDB
INA
Tbio
Novelty:  0.00708581
Score:  0.855
Data Source:  STRINGDB
DLGAP1
Tbio
Novelty:  0.01576595
Score:  0.852
Data Source:  STRINGDB
HOMER1
Tbio
Novelty:  0.00264721
Score:  0.786
Data Source:  STRINGDB
CAMK2A
Tchem
Family:  Kinase
Novelty:  0.00534906
Score:  0.746
Data Source:  STRINGDB
GRIA1
Tclin
Family:  IC
Novelty:  0.0005008
Score:  0.707
Data Source:  STRINGDB
GNAI3
Tbio
Novelty:  0.03484857
Score:  0.661
Data Source:  STRINGDB
GRIN2B
Tclin
Family:  IC
Novelty:  0.00035058
Score:  0.645
Data Source:  STRINGDB
Publication Statistics
PubMed Score  13.20

PubMed score by year
PubTator Score  4.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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