Tbio ZYG11B Protein zyg-11 homolog B

Protein Summary

Description

Probably acts as target recruitment subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC.

Uniprot Accession IDs

• Q9C0D3
• Q8N2X3
• Q9H8L8

Gene Name

• ZYG11B

Ensembl ID

• ENST00000294353
• ENSP00000294353
• ENSG00000162378

Symbol

• KIAA1730
• ZYG11

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.95
transcription factor perturbation	0.8
cellular component	0.77
cell type or tissue	0.72
virus perturbation	0.72

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.51   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 54   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.51   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0