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Tbio
PHACTR1
Phosphatase and actin regulator 1

Protein Summary
Description
Binds actin monomers (G actin) and plays a role in the reorganization of the actin cytoskeleton and in formation of actin stress fibers. Plays a role in cell motility. Plays a role in the formation of tubules by endothelial cells. Regulates PPP1CA activity. Required for normal cell survival. The protein encoded by this gene is a member of the phosphatase and actin regulator family of proteins. This family member can bind actin and regulate the reorganization of the actin cytoskeleton. It plays a role in tubule formation and in endothelial cell survival. Polymorphisms in this gene are associated with susceptibility to myocardial infarction, coronary artery disease and cervical artery dissection. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332995
  • ENSP00000329880
  • ENSG00000112137
  • ENST00000379350
  • ENSP00000368655
  • ENST00000634438
  • ENSP00000489436
  • ENSG00000282833
  • ENST00000635308
  • ENSP00000489293

Symbol
  • KIAA1733
  • RPEL1
  • RPEL
  • RPEL1
  • EIEE70
  • dJ257A7.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
phenotype
0.84
PubMedID
0.77
kinase perturbation
0.76
transcription factor perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122.14   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 59   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122.14   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 59   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (67)
ACTA1
Tbio
Novelty:  0.00111813
Score:  0.977
Data Source:  STRINGDB
PPP1CA
Tchem
Family:  Enzyme
Novelty:  0.00354658
Score:  0.83
Data Source:  STRINGDB
ACTA2
Tbio
Novelty:  0.00199354
Score:  0.814
Data Source:  STRINGDB
ACTG2
Tbio
Novelty:  0.00304944
Score:  0.809
Data Source:  STRINGDB
ACTC1
Tbio
Novelty:  0.00188036
Score:  0.801
Data Source:  STRINGDB
PPP1CB
Tbio
Family:  Enzyme
Novelty:  0.0122614
Score:  0.76
Data Source:  STRINGDB
MRTFB
Tbio
Novelty:  0.02702072
Score:  0.751
Data Source:  STRINGDB
ACTB
Tbio
Novelty:  0.00006048
Score:  0.732
Data Source:  STRINGDB
ACTG1
Tbio
Novelty:  0.00086444
Score:  0.732
Data Source:  STRINGDB
ANKS1A
Tbio
Novelty:  0.01972212
Score:  0.715
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
14
6
4
1.1
99
4
2
0
1.1
93.6
chronotype measurement
2
3
1
1
93.4
coronary artery calcification
2
1
3
74.5
4
1
0
1.1
74.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
99
0
1.1
93.6
chronotype measurement
1
1
93.4
coronary artery calcification
3
74.5
0
1.1
74.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
phosphatase and actin regulator 1
700226
Mouse
MGI:2659021
218194
Dog
phosphatase and actin regulator 1
VGNC:49769
478723
Cow
phosphatase and actin regulator 1
VGNC:32804
537594
Pig
phosphatase and actin regulator 1
100153737
Species
Name
OMA
EggNOG
Inparanoid
Macaque
phosphatase and actin regulator 1
Mouse
Dog
phosphatase and actin regulator 1
Cow
phosphatase and actin regulator 1
Pig
phosphatase and actin regulator 1
Publication Statistics
PubMed Score 122.14
PubMed score by year
PubTator Score 59.76
PubTator score by year
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Related Publications
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PMID
Year
Title