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Tbio
UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

Protein Summary
Description
E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853).
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
interacting protein
0.84
kinase perturbation
0.76
transcription factor binding site profile
0.75
transcription factor
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.12   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.12   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
3
3
53.5
lymphocyte percentage of leukocytes
2
1
2
51.4
reticulocyte count
1
2
2
42.6
leukocyte count
1
1
1
35
1
1
1
33.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
53.5
lymphocyte percentage of leukocytes
2
51.4
reticulocyte count
2
42.6
leukocyte count
1
35
1
33.9
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ubiquitin conjugating enzyme E2 O
710529
Mouse
MGI:2444266
217342
Rat
RGD:1310297
303689
Dog
ubiquitin conjugating enzyme E2 O
VGNC:48060
483330
Horse
ubiquitin conjugating enzyme E2 O
VGNC:24725
100058843
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ubiquitin conjugating enzyme E2 O
Mouse
Rat
Dog
ubiquitin conjugating enzyme E2 O
Horse
ubiquitin conjugating enzyme E2 O
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9C0C9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Gene Ontology Terms (13)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (368)
1 – 10 of 368
CAVIN1
Tbio
Family: Enzyme
Novelty: 0.00780634
p_int: 0.999998457
p_ni: 0.000001543
Data Source: BioPlex
JPH4
Tbio
Novelty: 0.07699598
p_int: 0.999983728
p_ni: 0.000016272
Data Source: BioPlex
FGFRL1
Tbio
Novelty: 0.02178846
p_int: 0.999936193
p_ni: 0.000063807
Data Source: BioPlex
PLD1
Tchem
Family: Enzyme
Novelty: 0.00608142
p_int: 0.999771167
p_ni: 0.000228833
Data Source: BioPlex
PLEKHG4
Tbio
Novelty: 0.01065982
p_int: 0.999690457
p_ni: 0.000309542
Score: 0.159
Data Source: BioPlex,STRINGDB
LUC7L
Tbio
Novelty: 0.05748021
p_int: 0.998936256
p_ni: 0.001063744
Score: 0.154
Data Source: BioPlex,STRINGDB
E4F1
Tbio
Family: TF
Novelty: 0.02192338
p_int: 0.998809565
p_ni: 0.001190435
Score: 0.159
Data Source: BioPlex,STRINGDB
PRM2
Tbio
Novelty: 0.0050028
p_int: 0.998560614
p_ni: 0.001439386
Data Source: BioPlex
RPL18
Tbio
Novelty: 0.01765545
p_int: 0.997047374
p_ni: 0.002952626
Data Source: BioPlex
AKT2
Tchem
Family: Kinase
Novelty: 0.00167027
p_int: 0.995490647
p_ni: 0.004509353
Score: 0.26
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  18.12

PubMed score by year
PubTator Score  7.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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