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Tbio
AMBRA1
Activating molecule in BECN1-regulated autophagy protein 1

Protein Summary
Description
Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314845
  • ENSP00000318313
  • ENSG00000110497
  • ENST00000458649
  • ENSP00000415327
  • ENST00000528950
  • ENSP00000433945
  • ENST00000534300
  • ENSP00000431926

Symbol
  • KIAA1736
  • DCAF3
  • WDR94
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.88
biological process
0.67
cellular component
0.67
tissue sample
0.65
tissue
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.72   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 364   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.72   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 364   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0