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Tdark
CIPC
CLOCK-interacting pacemaker

Protein Summary
Description
Transcriptional repressor which may act as a negative-feedback regulator of CLOCK-ARNTL/BMAL1 transcriptional activity in the circadian-clock mechanism. May stimulate ARNTL/BMAL1-dependent phosphorylation of CLOCK. However, the physiogical relevance of these observations is unsure, since experiments in an animal model showed that CIPC is not critially required for basic circadian clock.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361786
  • ENSP00000355319
  • ENSG00000198894

Symbol
  • KIAA1737
  • KIAA1737
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.95
histone modification site profile
0.83
transcription factor
0.8
transcription factor perturbation
0.68
cell type or tissue
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.28   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 35   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.28   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 35   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (26)
NPAS2
Tbio
Family:  TF
Novelty:  0.00728451
p_int:  0.999999742
p_ni:  1e-9
p_wrong:  2.57e-7
Score:  0.531
Data Source:  BioPlex,STRINGDB
COPS5
Tchem
Novelty:  0.00406225
p_int:  0.999999335
p_ni:  6.65e-7
Score:  0.171
Data Source:  BioPlex,STRINGDB
CLOCK
Tbio
Family:  TF; Epigenetic
Novelty:  0.00159625
p_int:  0.999998242
p_ni:  0.000001757
p_wrong:  2e-9
Score:  0.984
Data Source:  BioPlex,STRINGDB
ARNTL2
Tbio
Family:  TF
Novelty:  0.0039351
p_int:  0.999996869
p_ni:  9.7e-8
p_wrong:  0.000003034
Score:  0.819
Data Source:  BioPlex,STRINGDB
ZMYM4
Tbio
Novelty:  0.08839944
p_int:  0.897610808
p_ni:  0.102388721
p_wrong:  4.71e-7
Score:  0.516
Data Source:  BioPlex,STRINGDB
COPE
Tbio
Novelty:  0.02037359
Score:  0.724
Data Source:  STRINGDB
ITGB1BP1
Tbio
Novelty:  0.03944856
Score:  0.7
Data Source:  STRINGDB
ASAP2
Tbio
Novelty:  0.02744569
Score:  0.697
Data Source:  STRINGDB
ZNF410
Tbio
Family:  TF
Novelty:  0.00850417
Score:  0.69
Data Source:  STRINGDB
VTA1
Tbio
Novelty:  0.01697854
Score:  0.636
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Circadian rhythm related genes
WikiPathways
Circadian rhythm related genes
WikiPathways
Circadian rhythm related genes
WikiPathways
Circadian rhythm related genes
WikiPathways
Circadian rhythm related genes
Name
Explore in Pharos
Explore in Source
Circadian rhythm related genes
Circadian rhythm related genes
Circadian rhythm related genes
Circadian rhythm related genes
Circadian rhythm related genes
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
1
2
58.4
mathematical ability
2
2
3
47.5
aspartate aminotransferase measurement
2
2
1
5.9
45.6
body mass index
1
1
1
42.3
C-reactive protein measurement
1
1
1
38.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
58.4
mathematical ability
3
47.5
aspartate aminotransferase measurement
1
5.9
45.6
body mass index
1
42.3
C-reactive protein measurement
1
38.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1919185
217732
Rat
RGD:1309492
314330
Dog
CLOCK interacting pacemaker
VGNC:39278
490802
Horse
CLOCK interacting pacemaker
VGNC:16554
100052011
Cow
CLOCK interacting pacemaker
VGNC:27370
506130
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
CLOCK interacting pacemaker
Horse
CLOCK interacting pacemaker
Cow
CLOCK interacting pacemaker
Publication Statistics
PubMed Score 47.28
PubMed score by year
PubTator Score 17.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title