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Tbio
SEMA4C
Semaphorin-4C

Protein Summary
Description
Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration (By similarity). Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305476
  • ENSP00000306844
  • ENSG00000168758

Symbol
  • KIAA1739
  • SEMAI
  • SEMAF
  • SEMAI
  • SEMACL1
  • M-SEMA-F
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
transcription factor perturbation
0.8
transcription factor
0.66
transcription factor binding site profile
0.66
PubMedID
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.34   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 151   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 76.34   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 151   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
calcium measurement
1
4
4
89.6
mathematical ability
3
1
3
53.7
serum non-albumin protein measurement
1
1
1
37.6
body height
1
1
1
32.7
birth weight
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
calcium measurement
4
89.6
mathematical ability
3
53.7
serum non-albumin protein measurement
1
37.6
body height
1
32.7
birth weight
1
31.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
semaphorin 4C
VGNC:6656
459423
Mouse
MGI:109252
20353
Rat
RGD:1562837
301346
Dog
semaphorin 4C
VGNC:45996
481343
Horse
semaphorin 4C
VGNC:51404
100146410
Species
Name
OMA
EggNOG
Inparanoid
Chimp
semaphorin 4C
Mouse
Rat
Dog
semaphorin 4C
Horse
semaphorin 4C
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9C0C4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (19)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (155)
1 – 10 of 155
NBEAL2
Tbio
Novelty:  0.05579364
p_int:  0.999999873
p_ni:  2e-9
p_wrong:  1.25e-7
Data Source:  BioPlex
NUB1
Tbio
Novelty:  0.00736082
p_int:  0.999995399
p_ni:  0.000003045
p_wrong:  0.000001556
Data Source:  BioPlex
TRIM9
Tbio
Family:  Enzyme
Novelty:  0.06250762
p_int:  0.999974871
p_ni:  0.000024673
p_wrong:  4.55e-7
Data Source:  BioPlex
MSTO1
Tbio
Novelty:  0.05914188
p_int:  0.999907917
p_ni:  0.000092083
p_wrong:  1e-9
Data Source:  BioPlex
HELLS
Tbio
Family:  Enzyme
Novelty:  0.01348077
p_int:  0.999843049
p_ni:  0.000156951
Data Source:  BioPlex
FLCN
Tbio
Novelty:  0.0022007
p_int:  0.999684493
p_ni:  0.000306398
p_wrong:  0.000009109
Data Source:  BioPlex
EXOC6
Tbio
Novelty:  0.01886811
p_int:  0.99965299
p_ni:  0.00034701
Data Source:  BioPlex
IKBKG
Tbio
Family:  Kinase
Novelty:  0.0006149
p_int:  0.999606906
p_ni:  0.000393055
p_wrong:  3.9e-8
Data Source:  BioPlex
SNX5
Tbio
Novelty:  0.04075649
p_int:  0.999601163
p_ni:  0.000398837
Data Source:  BioPlex
LGALS1
Tchem
Novelty:  0.00106509
p_int:  0.999386782
p_ni:  0.000613218
Data Source:  BioPlex
Publication Statistics
PubMed Score  76.34

PubMed score by year
PubTator Score  30.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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