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Tbio
TNKS1BP1
182 kDa tankyrase-1-binding protein

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358252
  • ENSP00000350990
  • ENSG00000149115
  • ENST00000532437
  • ENSP00000437271

Symbol
  • KIAA1741
  • TAB182
  • TAB182
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
1
protein complex
0.91
interacting protein
0.87
drug perturbation
0.71
cell line
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 190   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 190   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
4
4
91.9
pappalysin‐1 measurement
1
1
1
88.1
eosinophil percentage of leukocytes
2
3
3
80.7
mean corpuscular volume
1
1
1
53.3
high density lipoprotein cholesterol measurement
1
1
0
1.8
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
4
91.9
pappalysin‐1 measurement
1
88.1
eosinophil percentage of leukocytes
3
80.7
mean corpuscular volume
1
53.3
high density lipoprotein cholesterol measurement
0
1.8
39.6
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tankyrase 1 binding protein 1
748067
Macaque
tankyrase 1 binding protein 1
704825
Mouse
MGI:2446193
228140
Rat
RGD:1312021
295707
Dog
tankyrase 1 binding protein 1
VGNC:47682
483496
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tankyrase 1 binding protein 1
Macaque
tankyrase 1 binding protein 1
Mouse
Rat
Dog
tankyrase 1 binding protein 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9C0C2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Deadenylation of mRNA (R-HSA-429947)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deadenylation of mRNA
Reactome
Deadenylation-dependent mRNA decay
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism of RNA
Name
Explore in Pharos
Explore in Source
Deadenylation of mRNA
Deadenylation-dependent mRNA decay
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism of RNA
Gene Ontology Terms (19)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Protein-Protein Interactions (57)
1 – 10 of 57
NANOS2
Tbio
Novelty:  0.01489157
p_int:  0.999998343
p_ni:  0.000001657
Score:  0.588
Data Source:  BioPlex,STRINGDB
CNOT3
Tbio
Novelty:  0.02463568
p_int:  0.999997871
p_ni:  0.000002129
Score:  0.934
Data Source:  BioPlex,STRINGDB
CNOT11
Tbio
Novelty:  0.01687183
p_int:  0.999996445
p_ni:  0.000003555
Score:  0.99
Data Source:  BioPlex,STRINGDB
TOB1
Tbio
Novelty:  0.0163328
p_int:  0.999994502
p_ni:  0.000005498
Score:  0.976
Data Source:  BioPlex,STRINGDB
FANCD2OS
Tdark
Novelty:  9.51798561
p_int:  0.999993465
p_ni:  0.000006535
Data Source:  BioPlex
RIBC1
Tdark
Novelty:  0.40435429
p_int:  0.999987278
p_ni:  0.000012722
Score:  0.759
Data Source:  BioPlex,STRINGDB
CNOT10
Tdark
Novelty:  0.30195594
p_int:  0.999976746
p_ni:  0.000023254
Score:  0.977
Data Source:  BioPlex,STRINGDB
MMP7
Tchem
Family:  Enzyme
Novelty:  0.00080093
p_int:  0.999907035
p_ni:  0.000092965
Score:  0.759
Data Source:  BioPlex,STRINGDB
CAPZA2
Tbio
Novelty:  0.14014918
p_int:  0.999814362
p_ni:  0.000185638
Score:  0.38
Data Source:  BioPlex,STRINGDB
CNOT7
Tchem
Novelty:  0.04551853
p_int:  0.99976443
p_ni:  0.00023557
Score:  0.994
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  6.00

PubMed score by year
PubTator Score  1.34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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