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Tdark
CFAP74
Cilia- and flagella-associated protein 74

Protein Summary
Description
As part of the central apparatus of the cilium axoneme may play a role in cilium movement.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000493964
  • ENSP00000417061
  • ENSG00000142609

Symbol
  • C1orf222
  • KIAA1751
  • C1orf222
  • KIAA1751
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.7
microRNA
0.57
disease
0.54
cellular component
0.44
chemical
0.42


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.28   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 33   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.28   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 33   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
2
3
93.9
influenza A (H1N1)
1
1
0
16.9
20.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
93.9
influenza A (H1N1)
0
16.9
20.3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9C0B2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (2)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (45)
1 – 10 of 45
SCNN1D
Tbio
Family: IC
Novelty: 0.06191685
p_int: 0.985974846
p_ni: 0.013750201
p_wrong: 0.000274953
Score: 0.25
Data Source: BioPlex,STRINGDB
GABRD
Tclin
Family: IC
Novelty: 0.0204242
Score: 0.713
Data Source: STRINGDB
C16orf97
Tdark
Novelty: 10.69767442
Score: 0.67
Data Source: STRINGDB
TMEM52
Tdark
Novelty: 0.78121918
Score: 0.669
Data Source: STRINGDB
CALML6
Tbio
Novelty: 0.17113396
Score: 0.612
Data Source: STRINGDB
CFAP46
Tdark
Novelty: 0.73818628
Score: 0.594
Data Source: STRINGDB
CFAP54
Tdark
Novelty: 0.91673101
Score: 0.594
Data Source: STRINGDB
ACTL7B
Tbio
Novelty: 0.05836037
Score: 0.571
Data Source: STRINGDB
CFAP221
Tbio
Novelty: 0.14501712
Score: 0.57
Data Source: STRINGDB
TSACC
Tbio
Novelty: 0.62833606
Score: 0.559
Data Source: STRINGDB
Publication Statistics
PubMed Score  2.28

PubMed score by year
PubTator Score  0.23

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer