Tbio UNK RING finger protein unkempt homolog

Protein Summary

Description

Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes (PubMed:25737280).

Uniprot Accession IDs

• Q9C0B0

Gene Name

• UNK

Ensembl ID

• ENST00000589666
• ENSP00000464893
• ENSG00000132478

Symbol

• KIAA1753
• ZC3H5
• ZC3HDC5
• ZC3H5
• UNKEMPT
• ZC3HDC5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.93
cell line	0.77
virus perturbation	0.68
histone modification site profile	0.65
cellular component	0.6

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.88   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 70   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.88   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0