Tbio INO80B INO80 complex subunit B

Protein Summary

Description

Induces growth and cell cycle arrests at the G1 phase of the cell cycle. Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. This gene encodes a subunit of an ATP-dependent chromatin remodeling complex, INO80, which plays a role in DNA and nucleosome-activated ATPase activity and ATP-dependent nucleosome sliding. Readthrough transcription of this gene into the neighboring downstream gene, which encodes WW domain-binding protein 1, generates a non-coding transcript. [provided by RefSeq, Feb 2011]

Uniprot Accession IDs

• Q9C086

Gene Name

• INO80B

Ensembl ID

• ENST00000233331
• ENSP00000233331
• ENSG00000115274

Symbol

• HMGA1L4
• PAPA1
• ZNHIT4
• IES2
• PAPA1
• hIes2
• PAPA-1
• ZNHIT4
• HMGA1L4
• HMGIYL4
• PAP-1BP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.72
transcription factor binding site profile	0.68
transcription factor perturbation	0.68
tissue sample	0.66
hub protein	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.29   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 62   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.29   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 62   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0