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Tbio
KRT23
Keratin, type I cytoskeletal 23

Protein Summary
Description
The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000209718
  • ENSP00000209718
  • ENSG00000108244
  • ENST00000436344
  • ENSP00000414056
  • ENST00000571258
  • ENSP00000460637
  • ENSG00000263309
  • ENST00000574480
  • ENSP00000459021

Symbol
  • K23
  • CK23
  • HAIK1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
PubMedID
0.73
kinase perturbation
0.66
small molecule perturbation
0.59
virus perturbation
0.55


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.92   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 263   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.92   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 263   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
keratin 23
VGNC:50415
455040
Macaque
keratin 23
702724
Mouse
MGI:2148866
94179
Rat
RGD:1308838
287678
Dog
keratin 23
VGNC:42522
491005
Species
Name
OMA
EggNOG
Inparanoid
Chimp
keratin 23
Macaque
keratin 23
Mouse
Rat
Dog
keratin 23
Pathways (4)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Keratinization
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (72)
1 – 10 of 72
KRT6B
Tbio
Novelty: 0.00152754
Score: 0.923
Data Source: STRINGDB
KRT78
Tbio
Novelty: 0.08006367
Score: 0.92
Data Source: STRINGDB
KRT6A
Tbio
Novelty: 0.00789111
Score: 0.92
Data Source: STRINGDB
KRT80
Tbio
Novelty: 0.08480792
Score: 0.919
Data Source: STRINGDB
KRT6C
Tbio
Novelty: 0.11659743
Score: 0.919
Data Source: STRINGDB
KRT8
Tbio
Novelty: 0.00093008
Score: 0.918
Data Source: STRINGDB
KRT4
Tbio
Novelty: 0.00434637
Score: 0.916
Data Source: STRINGDB
KRT7
Tbio
Novelty: 0.00039796
Score: 0.915
Data Source: STRINGDB
KRT5
Tbio
Novelty: 0.00072336
Score: 0.915
Data Source: STRINGDB
KRT2
Tbio
Novelty: 0.01448252
Score: 0.914
Data Source: STRINGDB
Publication Statistics
PubMed Score  20.92

PubMed score by year
PubTator Score  37.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer