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Tbio
NKX6-2
Homeobox protein Nkx-6.2

Protein Summary
Description
Transcription factor with repressor activity involved in the regulation of axon-glial interactions at myelin paranodes in oligodendrocytes. Binds to the consensus DNA sequence 5'-(A/T)TTAATGA-3'. In oligodendrocytes, binds to MBP and PLP1 promoter regions.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368592
  • ENSP00000357581
  • ENSG00000148826

Symbol
  • GTX
  • NKX6B
  • GTX
  • NKX6B
  • SPAX8
  • NKX6.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.73
protein domain
0.73
biological process
0.66
gene perturbation
0.62
PubMedID
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.47   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 73   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.47   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (18)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (111)
1 – 10 of 111
NEUROG3
Tbio
Family: TF
Novelty: 0.00341077
Score: 0.901
Data Source: STRINGDB
GCG
Tchem
Novelty: 0.00004879
Score: 0.826
Data Source: STRINGDB
NEUROD1
Tbio
Family: TF
Novelty: 0.00188624
Score: 0.778
Data Source: STRINGDB
OLIG2
Tbio
Family: TF
Novelty: 0.0015221
Score: 0.775
Data Source: STRINGDB
ISL1
Tbio
Family: TF
Novelty: 0.00169431
Score: 0.755
Data Source: STRINGDB
INSM1
Tbio
Family: TF
Novelty: 0.00146417
Score: 0.737
Data Source: STRINGDB
SLC2A2
Tchem
Family: Transporter
Novelty: 0.00103579
Score: 0.714
Data Source: STRINGDB
IRX3
Tbio
Family: TF
Novelty: 0.01150002
Score: 0.711
Data Source: STRINGDB
MAFA
Tbio
Family: TF
Novelty: 0.0338023
Score: 0.709
Data Source: STRINGDB
SST
Tbio
Novelty: 0.00005944
Score: 0.704
Data Source: STRINGDB
Publication Statistics
PubMed Score  158.47

PubMed score by year
PubTator Score  19.66

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer