You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TRIM2
Tripartite motif-containing protein 2

Protein Summary
Description
UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. It plays a neuroprotective role and functions as an E3-ubiquitin ligase in proteasome-mediated degradation of target proteins. Mutations in this gene can cause early-onset axonal neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338700
  • ENSP00000339659
  • ENSG00000109654
  • ENST00000437508
  • ENSP00000415812

Symbol
  • KIAA0517
  • RNF86
  • CMT2R
  • RNF86
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
transcription factor perturbation
0.99
small molecule perturbation
0.96
virus perturbation
0.95
microRNA
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.18   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 298   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.18   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 298   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (157)
TRIM3
Tbio
Novelty:  0.0188159
p_int:  0.999999999
p_wrong:  1e-9
Score:  0.704
Data Source:  BioPlex,STRINGDB
NUFIP1
Tbio
Novelty:  0.11726869
p_int:  0.964149505
p_ni:  4.3e-8
p_wrong:  0.035850452
Score:  0.179
Data Source:  BioPlex,STRINGDB
PML
Tbio
Novelty:  0.00285474
Score:  0.915
Data Source:  STRINGDB
OAS2
Tbio
Family:  Enzyme
Novelty:  0.01673393
Score:  0.912
Data Source:  STRINGDB
OASL
Tbio
Family:  Enzyme
Novelty:  0.01502223
Score:  0.909
Data Source:  STRINGDB
NCAM1
Tbio
Novelty:  0.00020994
Score:  0.908
Data Source:  STRINGDB
IRF7
Tbio
Family:  TF
Novelty:  0.0021839
Score:  0.907
Data Source:  STRINGDB
GBP4
Tbio
Novelty:  0.02747076
Score:  0.907
Data Source:  STRINGDB
IRF3
Tbio
Family:  TF
Novelty:  0.00099474
Score:  0.906
Data Source:  STRINGDB
HLA-DPA1
Tbio
Novelty:  0.01080446
Score:  0.904
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon gamma signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon gamma signaling
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
5
2
5
81.1
alkaline phosphatase measurement
1
1
1
67.1
high density lipoprotein cholesterol measurement
2
2
2
40.5
low density lipoprotein cholesterol measurement
1
1
1
38.2
total cholesterol measurement
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
5
81.1
alkaline phosphatase measurement
1
67.1
high density lipoprotein cholesterol measurement
2
40.5
low density lipoprotein cholesterol measurement
1
38.2
total cholesterol measurement
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1933163
80890
Rat
RGD:1310981
361970
Horse
tripartite motif containing 2
VGNC:24494
100062188
Cow
tripartite motif containing 2
VGNC:36318
538617
Pig
tripartite motif containing 2
100627416
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
tripartite motif containing 2
Cow
tripartite motif containing 2
Pig
tripartite motif containing 2
Publication Statistics
PubMed Score 36.18
PubMed score by year
PubTator Score 12.14
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title