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Tbio
TRIM4
E3 ubiquitin-protein ligase TRIM4

Protein Summary
Description
E3 ubiquitin-protein ligase. Mediates 'Lys-63'-linked polyubiquitination of the innate immune receptor DDX58, this linkage doesn't lead to proteasomal degradation but seems to enhance IFN induction. The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Its function has not been identified. Alternatively spliced transcript variants that encode different isoforms have been described.[provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000349062
  • ENSP00000275736
  • ENSG00000146833
  • ENST00000354241
  • ENSP00000346186
  • ENST00000355947
  • ENSP00000348216

Symbol
  • RNF87
  • RNF87
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
trait
0.75
tissue sample
0.63
cell type or tissue
0.53
small molecule perturbation
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.77   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 201   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.77   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (283)
1 – 10 of 283
RAB31
Tbio
Family:  Enzyme
Novelty:  0.03673084
p_int:  0.999995738
p_ni:  0.000004262
Score:  0.228
Data Source:  BioPlex,STRINGDB
TRAK1
Tbio
Novelty:  0.03561577
p_int:  0.999990546
p_ni:  0.000009454
Data Source:  BioPlex
P4HB
Tchem
Family:  Enzyme
Novelty:  0.00107905
p_int:  0.999990521
p_ni:  0.000009479
Score:  0.38
Data Source:  BioPlex,STRINGDB
LTBR
Tbio
Novelty:  0.003823
p_int:  0.99972856
p_ni:  0.000271377
p_wrong:  6.3e-8
Data Source:  BioPlex
RAB39B
Tbio
Family:  Enzyme
Novelty:  0.02362498
p_int:  0.999037669
p_ni:  0.000962285
p_wrong:  4.5e-8
Score:  0.151
Data Source:  BioPlex,STRINGDB
FPR2
Tchem
Family:  GPCR
Novelty:  0.00228744
p_int:  0.995784098
p_ni:  0.000707387
p_wrong:  0.003508516
Data Source:  BioPlex
TRIM69
Tbio
Family:  Enzyme
Novelty:  0.18807436
p_int:  0.994518501
p_ni:  0.004624479
p_wrong:  0.00085702
Score:  0.923
Data Source:  BioPlex,STRINGDB
MEX3C
Tbio
Family:  Enzyme
Novelty:  0.13082235
Score:  0.958
Data Source:  STRINGDB
TRIM9
Tbio
Family:  Enzyme
Novelty:  0.06250762
Score:  0.932
Data Source:  STRINGDB
UBE2N
Tchem
Novelty:  0.00620946
Score:  0.921
Data Source:  STRINGDB
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum metabolite measurement
1
2
3
85.8
metabolite measurement
1
1
1
82.4
testosterone measurement
1
1
1
81.6
ticagrelor measurement
1
2
2
63.9
estrone measurement
1
1
0
3.6
59.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum metabolite measurement
3
85.8
metabolite measurement
1
82.4
testosterone measurement
1
81.6
ticagrelor measurement
2
63.9
estrone measurement
0
3.6
59.9
Find similar targets by:
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
tripartite motif containing 4
709962
Dog
tripartite motif containing 4
VGNC:47820
608654
Horse
tripartite motif containing 4
VGNC:24508
102147803
Pig
tripartite motif containing 4
100525393
Species
Name
OMA
EggNOG
Inparanoid
Macaque
tripartite motif containing 4
Dog
tripartite motif containing 4
Horse
tripartite motif containing 4
Pig
tripartite motif containing 4
Publication Statistics
PubMed Score 7.77
PubMed score by year
PubTator Score 4.25
PubTator score by year