NLRP1
NACHT, LRR and PYD domains-containing protein 1
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
molecular function | 0.95 | ||
protein domain | 0.92 | ||
biological process | 0.8 | ||
cell type or tissue | 0.66 | ||
biological term | 0.61 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Immune System | ||||
Reactome | Inflammasomes | ||||
Reactome | Innate Immune System | ||||
Reactome | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | ||||
Reactome | The NLRP1 inflammasome | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Immune System | ||||
Inflammasomes | ||||
Innate Immune System | ||||
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | ||||
The NLRP1 inflammasome | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | HGNC | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
myeloid white cell count | 1 | 1 | 1 | 78.1 | |||||
leukocyte count | 1 | 1 | 1 | 73.9 | |||||
neutrophil count | 2 | 1 | 2 | 64.9 | |||||
body mass index | 1 | 1 | 1 | 38.8 | |||||
hip bone size | 1 | 1 | 1 | 35 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
myeloid white cell count | 1 | 78.1 | |||||
leukocyte count | 1 | 73.9 | |||||
neutrophil count | 2 | 64.9 | |||||
body mass index | 1 | 38.8 | |||||
hip bone size | 1 | 35 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | NLR family pyrin domain containing 1 | VGNC:12556 | 468451 | |||||
Mouse | MGI:2684861 | 195046 | ||||||
Mouse | MGI:3582959 | 637515 | ||||||
Dog | NLR family pyrin domain containing 1 | VGNC:43845 | 489449 | |||||
Horse | NLR family pyrin domain containing 1 [Source:HGNC Symbol;Acc:HGNC:14374] | |||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | NLR family pyrin domain containing 1 | |||||
Mouse | ||||||
Mouse | ||||||
Dog | NLR family pyrin domain containing 1 | |||||
Horse | NLR family pyrin domain containing 1 [Source:HGNC Symbol;Acc:HGNC:14374] | |||||
PMID | Year | Title |
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