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Tbio
NLRP1
NACHT, LRR and PYD domains-containing protein 1

Protein Summary
Description
As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP1, CASP1, and possibly PYCARD. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP1 inflammasome is also required for HMGB1 secretion. The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death (PubMed:22665479, PubMed:17418785). May be activated by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, in a NOD2-dependent manner (PubMed:18511561). Contrary to its mouse ortholog, not activated by Bacillus anthracis lethal toxin (PubMed:19651869). It is unclear whether isoform 2 is involved in inflammasome formation. It is ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262467
  • ENSP00000262467
  • ENSG00000091592
  • ENST00000269280
  • ENSP00000269280
  • ENST00000345221
  • ENSP00000324366
  • ENST00000354411
  • ENSP00000346390
  • ENST00000544378
  • ENSP00000442029
  • ENST00000571451
  • ENSP00000459661
  • ENST00000572272
  • ENSP00000460475
  • ENST00000577119
  • ENSP00000460216
  • ENST00000613500
  • ENSP00000483359
  • ENST00000617618
  • ENSP00000478516
  • ENST00000619223
  • ENSP00000484692

Symbol
  • CARD7
  • DEFCAP
  • KIAA0926
  • NAC
  • NALP1
  • NAC
  • MSPC
  • AIADK
  • CARD7
  • CIDED
  • NALP1
  • SLEV1
  • DEFCAP
  • PP1044
  • VAMAS1
  • CLR17.1
  • DEFCAP-L/S
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
protein domain
0.92
biological process
0.8
cell type or tissue
0.66
biological term
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 237.55   (req: < 5)
Gene RIFs: 88   (req: <= 3)
Antibodies: 228   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 237.55   (req: >= 5)
Gene RIFs: 88   (req: > 3)
Antibodies: 228   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
1
1
78.1
leukocyte count
1
1
1
73.9
neutrophil count
2
1
2
64.9
body mass index
1
1
1
38.8
hip bone size
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
78.1
leukocyte count
1
73.9
neutrophil count
2
64.9
body mass index
1
38.8
hip bone size
1
35
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NLR family pyrin domain containing 1
VGNC:12556
468451
Mouse
MGI:2684861
195046
Mouse
MGI:3582959
637515
Dog
NLR family pyrin domain containing 1
VGNC:43845
489449
Horse
NLR family pyrin domain containing 1 [Source:HGNC Symbol;Acc:HGNC:14374]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NLR family pyrin domain containing 1
Mouse
Mouse
Dog
NLR family pyrin domain containing 1
Horse
NLR family pyrin domain containing 1 [Source:HGNC Symbol;Acc:HGNC:14374]
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9C000-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Inflammasomes
Reactome
Innate Immune System
Reactome
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
Reactome
The NLRP1 inflammasome
Name
Explore in Pharos
Explore in Source
Immune System
Inflammasomes
Innate Immune System
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
The NLRP1 inflammasome
Protein-Protein Interactions (68)
1 – 10 of 68
CASP1
Tchem
Family:  Enzyme
Novelty:  0.00034643
Score:  0.994
Data Source:  STRINGDB
CASP5
Tchem
Family:  Enzyme
Novelty:  0.00734661
Score:  0.987
Data Source:  STRINGDB
AIM2
Tbio
Novelty:  0.00360474
Score:  0.984
Data Source:  STRINGDB
NLRC4
Tbio
Novelty:  0.0032237
Score:  0.977
Data Source:  STRINGDB
BCL2L1
Tchem
Novelty:  0.00018414
Score:  0.971
Data Source:  Reactome,STRINGDB
PYCARD
Tbio
Novelty:  0.00719985
Score:  0.941
Data Source:  STRINGDB
BCL2
Tclin
Novelty:  0.00608635
Score:  0.938
Data Source:  Reactome,STRINGDB
NLRP3
Tchem
Novelty:  0.00043957
Score:  0.922
Data Source:  STRINGDB
NLRP9
Tbio
Novelty:  0.075833
Score:  0.917
Data Source:  STRINGDB
DHX33
Tbio
Family:  Enzyme
Novelty:  0.07473852
Score:  0.915
Data Source:  STRINGDB
Publication Statistics
PubMed Score  237.55

PubMed score by year
PubTator Score  120

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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