You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TRIM31
E3 ubiquitin-protein ligase TRIM31

Protein Summary
Description
Regulator of Src-induced anchorage independent cell growth (By similarity). May have E3 ubiquitin-protein ligase activity. This gene encodes a protein that functions as an E3 ubiquitin-protein ligase. This gene shows altered expression in certain tumors and may be a negative regulator of cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357569
  • ENSP00000350182
  • ENSG00000137397
  • ENST00000376734
  • ENSP00000365924
  • ENSG00000204616
  • ENST00000433864
  • ENSP00000390551
  • ENSG00000233573
  • ENST00000445679
  • ENSP00000409501
  • ENSG00000224168
  • ENST00000449412
  • ENSP00000398677
  • ENSG00000223531
  • ENST00000453266
  • ENSP00000391685
  • ENSG00000225130
  • ENST00000551027
  • ENSP00000446675

Symbol
  • C6orf13
  • RNF
  • RNF
  • HCG1
  • HCGI
  • C6orf13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
virus perturbation
0.68
gene perturbation
0.67
phenotype
0.63
biological process
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 169.99   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 171   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 169.99   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 171   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon gamma signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon gamma signaling
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (165)
1 – 10 of 165
HLA-F
Tbio
Novelty: 0.01349191
Score: 0.951
Data Source: STRINGDB
HLA-E
Tbio
Novelty: 0.00263667
Score: 0.95
Data Source: STRINGDB
HLA-A
Tbio
Novelty: 0.00378961
Score: 0.948
Data Source: STRINGDB
HLA-A
Tbio
Novelty: 0.00378961
Score: 0.948
Data Source: STRINGDB
HLA-A
Tbio
Novelty: 0.00378961
Score: 0.948
Data Source: STRINGDB
HLA-A
Tbio
Novelty: 0.00378961
Score: 0.948
Data Source: STRINGDB
HLA-A
Tbio
Novelty: 0.00378961
Score: 0.948
Data Source: STRINGDB
HLA-A
Tbio
Novelty: 0.00378961
Score: 0.948
Data Source: STRINGDB
HLA-A
Tbio
Novelty: 0.00378961
Score: 0.948
Data Source: STRINGDB
HLA-A
Tbio
Novelty: 0.00378961
Score: 0.948
Data Source: STRINGDB
Publication Statistics
PubMed Score  169.99

PubMed score by year
PubTator Score  17.34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer