Tbio UCK2 Uridine-cytidine kinase 2

Protein Summary

Description

Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine. This gene encodes a pyrimidine ribonucleoside kinase. The encoded protein (EC 2.7.1.48) catalyzes phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP), respectively.[provided by RefSeq, Oct 2010]

Uniprot Accession IDs

• Q9BZX2
• Q5VV91
• Q7KZV3
• Q92528
• Q96KG5
• Q9BU42
• UCK 2

Gene Name

• UCK2

Ensembl ID

• ENST00000367879
• ENSP00000356853
• ENSG00000143179
• ENST00000469256
• ENSP00000476692
• ENST00000470820
• ENSP00000476327

Symbol

• UMPK
• UK
• UMPK
• TSA903

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.99
kinase perturbation	0.97
transcription factor binding site profile	0.95
PubMedID	0.92
molecular function	0.9

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Nucleotide Kinase / Uridine-cytidine Kinase 2

Protein / Transferase / Glycosyltransferase / Uridine-cytidine Kinase 2

DTO Classes

Protein / Kinase / Non-protein Kinase / Nucleoside Kinase / Uridine Kinase Family / Uridine-cytidine Kinase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.04   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 177   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.04   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0