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Tbio
UCK2
Uridine-cytidine kinase 2

Protein Summary
Description
Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine. This gene encodes a pyrimidine ribonucleoside kinase. The encoded protein (EC 2.7.1.48) catalyzes phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP), respectively.[provided by RefSeq, Oct 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367879
  • ENSP00000356853
  • ENSG00000143179
  • ENST00000469256
  • ENSP00000476692
  • ENST00000470820
  • ENSP00000476327

Symbol
  • UMPK
  • UK
  • UMPK
  • TSA903
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
kinase perturbation
0.97
transcription factor binding site profile
0.95
PubMedID
0.92
molecular function
0.9


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.42   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 177   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.42   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
9
5
10
98.5
3
2
0
1.4
94.8
2
1
0
1.4
85.6
Antiglaucoma preparations and miotics use measurement
1
1
1
82.3
2
1
0
1.2
61.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
10
98.5
0
1.4
94.8
0
1.4
85.6
Antiglaucoma preparations and miotics use measurement
1
82.3
0
1.2
61.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
uridine-cytidine kinase 2
VGNC:7021
748077
Macaque
uridine-cytidine kinase 2
695725
Mouse
MGI:1931744
80914
Rat
RGD:620742
304944
Horse
uridine-cytidine kinase 2
VGNC:24763
100058590
Species
Name
OMA
EggNOG
Inparanoid
Chimp
uridine-cytidine kinase 2
Macaque
uridine-cytidine kinase 2
Mouse
Rat
Horse
uridine-cytidine kinase 2
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BZX2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (13)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleotide salvage
Reactome
Pyrimidine salvage
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleotide salvage
Pyrimidine salvage
Gene Ontology Terms (8)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (79)
1 – 10 of 79
UPRT
Tbio
Family:  Enzyme
Novelty:  0.00506163
p_int:  0.999999997
p_ni:  3e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
UCK1
Tbio
Family:  Kinase
Novelty:  0.10536869
p_int:  0.999997988
p_wrong:  0.000002012
Score:  0.97
Data Source:  BioPlex,STRINGDB
UCKL1
Tbio
Family:  Kinase
Novelty:  0.18522799
p_int:  0.99998485
p_ni:  0.000015149
p_wrong:  1e-9
Score:  0.975
Data Source:  BioPlex,STRINGDB
IAH1
Tbio
Family:  Enzyme
Novelty:  0.10541696
p_int:  0.999957796
p_ni:  0.000042102
p_wrong:  1.02e-7
Score:  0.69
Data Source:  BioPlex,STRINGDB
VARS2
Tbio
Family:  Enzyme
Novelty:  0.00941946
p_int:  0.999884367
p_ni:  0.000115631
p_wrong:  1e-9
Score:  0.442
Data Source:  BioPlex,STRINGDB
UPP1
Tchem
Family:  Enzyme
Novelty:  0.01384975
Score:  0.979
Data Source:  STRINGDB
UMPS
Tclin
Family:  Enzyme
Novelty:  0.00848756
Score:  0.975
Data Source:  STRINGDB
CDA
Tclin
Family:  Enzyme
Novelty:  0.00280981
Score:  0.955
Data Source:  STRINGDB
ENTPD3
Tbio
Family:  Enzyme
Novelty:  0.01673548
Score:  0.921
Data Source:  STRINGDB
CMPK2
Tbio
Family:  Kinase
Novelty:  0.01285082
Score:  0.92
Data Source:  STRINGDB
Publication Statistics
PubMed Score  48.42

PubMed score by year
PubTator Score  72.27

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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