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Tbio
CD244
Natural killer cell receptor 2B4

Protein Classes
Protein Summary
Description
Heterophilic receptor of the signaling lymphocytic activation molecule (SLAM) family; its ligand is CD48. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Acts as activating natural killer (NK) cell receptor (PubMed:10359122, PubMed:8376943, PubMed:11714776). Activating function implicates association with SH2D1A and FYN (PubMed:15713798). Downstreaming signaling involves predominantly VAV1, and, to a lesser degree, INPP5D/SHIP1 and CBL. Signal attenuation in the absence of SH2D1A is proposed to be dependent on INPP5D and to a lesser extent PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:10934222, PubMed:15713798). Stimulates NK cell cytotoxicity, production of IFN-gamma ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322302
  • ENSP00000313619
  • ENSG00000122223
  • ENST00000368033
  • ENSP00000357012
  • ENST00000368034
  • ENSP00000357013
  • ENST00000492063
  • ENSP00000432636

Symbol
  • 2B4
  • 2B4
  • NAIL
  • Nmrk
  • NKR2B4
  • SLAMF4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
biological term
0.68
gene perturbation
0.6
kinase perturbation
0.54
transcription factor
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 208.28   (req: < 5)
Gene RIFs: 69   (req: <= 3)
Antibodies: 667   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 208.28   (req: >= 5)
Gene RIFs: 69   (req: > 3)
Antibodies: 667   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (3)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Hemostasis
Gene Ontology Terms (14)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (149)
1 – 10 of 149
CARD19
Tdark
Family: Enzyme
Novelty: 0.29473684
p_int: 0.999997983
p_ni: 0.000002006
p_wrong: 1.1e-8
Score: 0.635
Data Source: BioPlex,STRINGDB
POMT2
Tbio
Family: Enzyme
Novelty: 0.03313606
p_int: 0.999986366
p_ni: 0.000013634
Data Source: BioPlex
POMT1
Tbio
Family: Enzyme
Novelty: 0.02417298
p_int: 0.99994816
p_ni: 0.00005184
Data Source: BioPlex
PDXDC1
Tdark
Family: Enzyme
Novelty: 0.43701506
p_int: 0.999527546
p_ni: 0.000472454
Score: 0.158
Data Source: BioPlex,STRINGDB
MYADM
Tbio
Novelty: 0.09214874
p_int: 0.996323529
p_ni: 0.002661402
p_wrong: 0.001015069
Data Source: BioPlex
MTX3
Tdark
Novelty: 0.0360262
p_int: 0.989851933
p_ni: 0.010148066
Data Source: BioPlex
MTOR
Tclin
Family: Kinase
Novelty: 0.00014431
p_int: 0.974646484
p_ni: 0.025353516
Score: 0.183
Data Source: BioPlex,STRINGDB
MTX2
Tbio
Novelty: 0.02415503
p_int: 0.958717936
p_ni: 0.041282064
Score: 0.823
Data Source: BioPlex,STRINGDB
RNF213
Tbio
Family: Enzyme
Novelty: 0.00840705
p_int: 0.953443877
p_ni: 0.046556035
p_wrong: 8.8e-8
Score: 0.221
Data Source: BioPlex,STRINGDB
IMMT
Tbio
Novelty: 0.00144011
p_int: 0.952803723
p_ni: 0.047196277
Score: 0.819
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  208.28

PubMed score by year
PubTator Score  236.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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