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Tdark
TM6SF1
Transmembrane 6 superfamily member 1

Protein Summary
Description
May function as sterol isomerase.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322019
  • ENSP00000317000
  • ENSG00000136404
  • ENST00000565774
  • ENSP00000457477
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
gene perturbation
0.74
PubMedID
0.73
histone modification site profile
0.6
small molecule perturbation
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.02   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 74   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.02   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 74   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
2
2
62
glomerular filtration rate
1
1
1
50.6
1
1
0
1.1
26.6
BMI-adjusted hip circumference
1
1
1
17.8
smoking status measurement
2
1
2
17.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
62
glomerular filtration rate
1
50.6
0
1.1
26.6
BMI-adjusted hip circumference
1
17.8
smoking status measurement
2
17.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane 6 superfamily member 1
VGNC:1593
453601
Macaque
transmembrane 6 superfamily member 1
700147
Mouse
MGI:1933209
107769
Rat
RGD:1307978
361600
Dog
transmembrane 6 superfamily member 1
VGNC:47411
479058
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane 6 superfamily member 1
Macaque
transmembrane 6 superfamily member 1
Mouse
Rat
Dog
transmembrane 6 superfamily member 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BZW5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (2)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (27)
1 – 10 of 27
HAPLN4
Tbio
Novelty:  0.10810809
Score:  0.93
Data Source:  STRINGDB
TMEM182
Tdark
Novelty:  0.35321541
Score:  0.748
Data Source:  STRINGDB
TSPAN33
Tbio
Novelty:  0.17463296
Score:  0.646
Data Source:  STRINGDB
ELOVL6
Tchem
Novelty:  0.00817818
Score:  0.591
Data Source:  STRINGDB
RASGRF2
Tbio
Novelty:  0.02655658
Score:  0.587
Data Source:  STRINGDB
CDH15
Tbio
Novelty:  0.01904376
Score:  0.575
Data Source:  STRINGDB
LRRC52
Tbio
Family:  IC
Novelty:  0.15407898
Score:  0.574
Data Source:  STRINGDB
LYPLAL1
Tbio
Family:  Enzyme
Novelty:  0.0447394
Score:  0.544
Data Source:  STRINGDB
CILP2
Tbio
Novelty:  0.07992715
Score:  0.538
Data Source:  STRINGDB
TMEFF2
Tbio
Novelty:  0.02364703
Score:  0.531
Data Source:  STRINGDB
Publication Statistics
PubMed Score  3.02

PubMed score by year
PubTator Score  1.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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