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Tbio
TM6SF2
Transmembrane 6 superfamily member 2

Protein Summary
Description
Regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content (PubMed:24531328, PubMed:24927523). May function as sterol isomerase (PubMed:25566323).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389363
  • ENSP00000374014
  • ENSG00000213996
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.72
gene perturbation
0.71
tissue
0.59
histone modification site profile
0.51
cellular component
0.45


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.59   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 48   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.59   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 48   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (45)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
14
11
20
3.8
99.8
triglyceride measurement
18
10
28
8.2
99.6
total cholesterol measurement
9
6
13
4.4
99.4
apolipoprotein B measurement
2
4
4
98.5
serum alanine aminotransferase measurement
3
4
4
17.9
98.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
20
3.8
99.8
triglyceride measurement
28
8.2
99.6
total cholesterol measurement
13
4.4
99.4
apolipoprotein B measurement
4
98.5
serum alanine aminotransferase measurement
4
17.9
98.4
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane 6 superfamily member 2
VGNC:2228
736763
Macaque
transmembrane 6 superfamily member 2
719756
Mouse
MGI:1933210
107770
Rat
RGD:1597457
689029
Dog
transmembrane 6 superfamily member 2
VGNC:47412
609715
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane 6 superfamily member 2
Macaque
transmembrane 6 superfamily member 2
Mouse
Rat
Dog
transmembrane 6 superfamily member 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BZW4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (35)
1 – 10 of 35
HAPLN4
Tbio
Novelty:  0.10810809
Score:  0.937
Data Source:  STRINGDB
PNPLA3
Tbio
Family:  Enzyme
Novelty:  0.00180327
Score:  0.921
Data Source:  STRINGDB
LYPLAL1
Tbio
Family:  Enzyme
Novelty:  0.0447394
Score:  0.842
Data Source:  STRINGDB
MBOAT7
Tbio
Family:  Enzyme
Novelty:  0.01861411
Score:  0.836
Data Source:  STRINGDB
CILP2
Tbio
Novelty:  0.07992715
Score:  0.83
Data Source:  STRINGDB
GCKR
Tchem
Family:  Enzyme
Novelty:  0.00798717
Score:  0.748
Data Source:  STRINGDB
NCAN
Tbio
Novelty:  0.00401824
Score:  0.668
Data Source:  STRINGDB
BORCS8
Tdark
Novelty:  1.62939642
Score:  0.667
Data Source:  STRINGDB
KIAA1211
Tdark
Novelty:  0.83445472
Score:  0.647
Data Source:  STRINGDB
RNF157
Tbio
Novelty:  0.78586559
Score:  0.647
Data Source:  STRINGDB
Publication Statistics
PubMed Score  126.59

PubMed score by year
PubTator Score  61.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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