Tbio SLC13A1 Solute carrier family 13 member 1

Protein Summary

Description

Sodium/sulfate cotransporter that mediates sulfate reabsorption in the kidney. The protein encoded by this gene is an apical membrane Na(+)-sulfate cotransporter involved in sulfate homeostasis in the kidney. Defects in this gene lead to many pathophysiologic problems. [provided by RefSeq, May 2016]

Uniprot Accession IDs

• Q9BZW2
• Q9H5Z0

Gene Name

• SLC13A1

Ensembl ID

• ENST00000194130
• ENSP00000194130
• ENSG00000081800

Symbol

• NAS1
• NASI1
• NAS1
• NaSi-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.96
cell type or tissue	0.76
molecular function	0.76
trait	0.75
disease perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Solute Carrier Family 13 Member 1

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc13 Family Of Sodium-dependent Sulphate/carboxylate Transporters / Solute Carrier Family 13 Member 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.27   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 29   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.27   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 29   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0