Tbio UBXN6 UBX domain-containing protein 6

Protein Summary

Description

May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes (PubMed:26475856). As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation (PubMed:21822278, PubMed:23335559). It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins (PubMed:19275885). Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622).

Uniprot Accession IDs

• Q9BZV1
• D6W626
• Q96AH1
• Q96IK9
• Q9BZV0

Gene Name

• UBXN6

Ensembl ID

• ENST00000301281
• ENSP00000301281
• ENSG00000167671
• ENST00000394765
• ENSP00000378246

Symbol

• UBXD1
• UBXDC2
• UBXD1
• UBXDC2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.84
disease perturbation	0.79
cell type or tissue	0.74
transcription factor perturbation	0.74
cellular component	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.04   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 156   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.04   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0