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Tbio
UBXN6
UBX domain-containing protein 6

Protein Summary
Description
May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes (PubMed:26475856). As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation (PubMed:21822278, PubMed:23335559). It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins (PubMed:19275885). Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301281
  • ENSP00000301281
  • ENSG00000167671
  • ENST00000394765
  • ENSP00000378246

Symbol
  • UBXD1
  • UBXDC2
  • UBXD1
  • UBXDC2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
disease perturbation
0.79
cell type or tissue
0.74
transcription factor perturbation
0.74
cellular component
0.66


Related Tools
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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.32   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 156   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.32   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
UBX domain protein 6
VGNC:2417
455604
Macaque
UBX domain protein 6
715070
Mouse
MGI:1913780
66530
Rat
RGD:1590866
363332
Dog
UBX domain protein 6
VGNC:48101
485037
Species
Name
OMA
EggNOG
Inparanoid
Chimp
UBX domain protein 6
Macaque
UBX domain protein 6
Mouse
Rat
Dog
UBX domain protein 6
Gene Ontology Terms (13)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (60)
1 – 10 of 60
VCPKMT
Tbio
Family: Enzyme
Novelty: 0.37849297
p_int: 1
Score: 0.954
Data Source: BioPlex,STRINGDB
VCP
Tchem
Family: Enzyme
Novelty: 0.00103317
p_int: 0.999999971
p_ni: 2.9e-8
Score: 0.996
Data Source: BioPlex,STRINGDB
FAM104A
Tdark
Novelty: 0.81293501
p_int: 0.99996971
p_ni: 1.9e-8
p_wrong: 0.000030271
Score: 0.847
Data Source: BioPlex,STRINGDB
UBXN2A
Tbio
Novelty: 0.52282698
p_int: 0.99982359
p_ni: 1.43e-7
p_wrong: 0.000176267
Score: 0.951
Data Source: BioPlex,STRINGDB
POR
Tbio
Family: Enzyme
Novelty: 0.00145147
p_int: 0.998452066
p_ni: 0.001547934
Score: 0.347
Data Source: BioPlex,STRINGDB
ASPSCR1
Tbio
Novelty: 0.01172319
p_int: 0.984585963
p_ni: 0.015413867
p_wrong: 1.7e-7
Score: 0.768
Data Source: BioPlex,STRINGDB
NSFL1C
Tbio
Novelty: 0.05494848
Score: 0.972
Data Source: STRINGDB
XPO6
Tbio
Novelty: 0.03229708
Score: 0.943
Data Source: STRINGDB
SVIP
Tbio
Novelty: 0.05269453
Score: 0.938
Data Source: STRINGDB
UBXN4
Tdark
Novelty: 0.16206743
Score: 0.903
Data Source: STRINGDB
Publication Statistics
PubMed Score  11.32

PubMed score by year
PubTator Score  8.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer