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Tbio
FOXP3
Forkhead box protein P3

Protein Summary
Description
Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2 (PubMed:15790681). Mediates transcriptional repression of IL2 via its association with histone acet ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376199
  • ENSP00000365372
  • ENSG00000049768
  • ENST00000376207
  • ENSP00000365380
  • ENST00000518685
  • ENSP00000428952
  • ENST00000557224
  • ENSP00000451208

Symbol
  • IPEX
  • JM2
  • AIID
  • IPEX
  • PIDX
  • XPID
  • DIETER
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
0.95
protein domain
0.85
tissue sample
0.77
tissue
0.69


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6131.81   (req: < 5)
Gene RIFs: 845   (req: <= 3)
Antibodies: 1751   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6131.81   (req: >= 5)
Gene RIFs: 845   (req: > 3)
Antibodies: 1751   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 65
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
forkhead box P3
574303
Mouse
MGI:1891436
20371
Rat
RGD:1562112
317382
Dog
forkhead box P3
VGNC:40967
491876
Horse
forkhead box P3
VGNC:18115
100052226
Species
Name
OMA
EggNOG
Inparanoid
Macaque
forkhead box P3
Mouse
Rat
Dog
forkhead box P3
Horse
forkhead box P3
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BZS1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (13)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
Reactome
RUNX1 regulates transcription of genes involved in WNT signaling
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
RUNX1 regulates transcription of genes involved in WNT signaling
Gene Ontology Terms (69)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (490)
1 – 10 of 490
FOXP1
Tbio
Family: TF
Novelty: 0.00337994
p_int: 0.999999837
p_ni: 1.63e-7
p_wrong: 1e-9
Score: 0.867
Data Source: BioPlex,STRINGDB
FOXP4
Tbio
Family: TF
Novelty: 0.02668451
p_int: 0.999999641
p_ni: 3.58e-7
p_wrong: 1e-9
Score: 0.885
Data Source: BioPlex,STRINGDB
FOXP2
Tbio
Family: TF
Novelty: 0.00190504
p_int: 0.999996603
p_ni: 8.69e-7
p_wrong: 0.000002528
Score: 0.846
Data Source: BioPlex,STRINGDB
SMYD2
Tchem
Family: Epigenetic
Novelty: 0.0192516
p_int: 0.983967596
p_ni: 0.006727601
p_wrong: 0.009304803
Score: 0.275
Data Source: BioPlex,STRINGDB
CDC23
Tbio
Novelty: 0.0168525
p_int: 0.834284016
p_ni: 0.164135445
p_wrong: 0.001580539
Score: 0.208
Data Source: BioPlex,STRINGDB
CTLA4
Tclin
Novelty: 0.00012781
Score: 0.997
Data Source: STRINGDB
IL2
Tchem
Novelty: 0.00003129
Score: 0.997
Data Source: STRINGDB
NFATC2
Tbio
Family: TF
Novelty: 0.00312526
Score: 0.996
Data Source: Reactome,STRINGDB
TNFRSF18
Tbio
Novelty: 0.00374323
Score: 0.993
Data Source: STRINGDB
IFNG
Tclin
Novelty: 0.00009731
Score: 0.986
Data Source: STRINGDB
Publication Statistics
PubMed Score  6131.81

PubMed score by year
PubTator Score  4143.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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