You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
BCL2L14
Apoptosis facilitator Bcl-2-like protein 14

Protein Summary
Description
Plays a role in apoptosis. The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Overexpression of this gene has been shown to induce apoptosis in cells. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported for this gene. [provided by RefSeq, May 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266434
  • ENSP00000266434
  • ENSG00000121380
  • ENST00000298566
  • ENSP00000298566
  • ENST00000308721
  • ENSP00000309132
  • ENST00000396367
  • ENSP00000379653
  • ENST00000589718
  • ENSP00000467086
  • ENST00000627413
  • ENSP00000486050
  • ENSG00000281449
  • ENST00000628315
  • ENSP00000485980
  • ENST00000628783
  • ENSP00000487330
  • ENST00000631251
  • ENSP00000486560
  • ENST00000631317
  • ENSP00000486796

Symbol
  • BCLG
  • BCLG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
tissue sample
0.81
PubMedID
0.65
cell type or tissue
0.57
gene perturbation
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.74   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 249   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.74   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 249   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
C7orf43
Tdark
Novelty:  1.11975505
p_int:  0.999988894
p_ni:  0.000011084
p_wrong:  2.2e-8
Score:  0.816
Data Source:  BioPlex,STRINGDB
TRAPPC9
Tbio
Novelty:  0.02703008
p_int:  0.999982955
p_ni:  0.000017045
Score:  0.782
Data Source:  BioPlex,STRINGDB
TRAPPC6B
Tbio
Novelty:  0.15086531
p_int:  0.999962853
p_ni:  0.000037147
Score:  0.895
Data Source:  BioPlex,STRINGDB
TRAPPC10
Tbio
Novelty:  0.03433058
p_int:  0.999904502
p_ni:  0.000095498
Score:  0.745
Data Source:  BioPlex,STRINGDB
TRAPPC4
Tbio
Novelty:  0.05749912
p_int:  0.999871681
p_ni:  0.000128319
Score:  0.763
Data Source:  BioPlex,STRINGDB
TRAPPC2L
Tdark
Novelty:  0.41040339
p_int:  0.999398796
p_ni:  0.00060111
p_wrong:  9.4e-8
Score:  0.826
Data Source:  BioPlex,STRINGDB
TRAPPC1
Tbio
Novelty:  0.09781468
p_int:  0.994997385
p_ni:  0.005002615
Score:  0.826
Data Source:  BioPlex,STRINGDB
TRAPPC5
Tdark
Novelty:  0.22558077
p_int:  0.994965227
p_ni:  0.005034557
p_wrong:  2.16e-7
Score:  0.83
Data Source:  BioPlex,STRINGDB
TRAPPC3
Tbio
Novelty:  0.0360262
p_int:  0.993653018
p_ni:  0.006346981
p_wrong:  1e-9
Score:  0.849
Data Source:  BioPlex,STRINGDB
TRAPPC2
Tbio
Novelty:  0.02016231
p_int:  0.992349532
p_ni:  0.007650464
p_wrong:  4e-9
Score:  0.827
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
TP53 Regulates Transcription of Cell Death Genes
Reactome
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
TP53 Regulates Transcription of Cell Death Genes
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
4
4
91.1
balding measurement
1
3
3
84
glomerular filtration rate
2
1
2
61.4
self reported educational attainment
1
1
1
27.3
phosphorus measurement
1
1
1
0.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
4
91.1
balding measurement
3
84
glomerular filtration rate
2
61.4
self reported educational attainment
1
27.3
phosphorus measurement
1
0.8
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BCL2 like 14
VGNC:12794
465293
Macaque
BCL2 like 14
695971
Mouse
MGI:1914063
66813
Rat
RGD:1562777
500348
Dog
BCL2 like 14
VGNC:38410
477693
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BCL2 like 14
Macaque
BCL2 like 14
Mouse
Rat
Dog
BCL2 like 14
Publication Statistics
PubMed Score 27.74
PubMed score by year
PubTator Score 14.61
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title