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Tbio
RTN4R
Reticulon-4 receptor

Protein Summary
Description
Receptor for RTN4, OMG and MAG (PubMed:12037567, PubMed:12068310, PubMed:12426574, PubMed:12089450, PubMed:16712417, PubMed:18411262, PubMed:12839991, PubMed:19052207). Functions as receptor for the sialylated gangliosides GT1b and GM1 (PubMed:18411262). Besides, functions as receptor for chondroitin sulfate proteoglycans (By similarity). Can also bind heparin (By similarity). Intracellular signaling cascades are triggered via the coreceptor NGFR (PubMed:12426574). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:16712417, PubMed:22325200). Mediates axonal growth inhibition (PubMed:12839991, PubMed:19052207, PubMed:28892071). Plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain development. Required for normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000043402
  • ENSP00000043402
  • ENSG00000040608

Symbol
  • NOGOR
  • NGR
  • NOGOR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.86
cell type or tissue
0.62
protein domain
0.58
cell line
0.56
transcription factor binding site profile
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 560.3   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 333   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 560.3   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 333   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (82)
1 – 10 of 82
FCGRT
Tclin
Novelty:  0.00105713
p_int:  0.979048378
p_ni:  0.001474604
p_wrong:  0.019477018
Data Source:  BioPlex
ARHGEF25
Tbio
Novelty:  0.02782136
p_int:  0.94887039
p_ni:  0.021891424
p_wrong:  0.029238186
Score:  0.412
Data Source:  BioPlex,STRINGDB
SOAT1
Tchem
Family:  Enzyme
Novelty:  0.00530755
p_int:  0.929042535
p_ni:  0.070955665
p_wrong:  0.0000018
Score:  0.188
Data Source:  BioPlex,STRINGDB
CKAP4
Tbio
Novelty:  0.02104039
p_int:  0.870173236
p_ni:  0.129826764
Data Source:  BioPlex
RTN4
Tbio
Novelty:  0.00080371
Score:  0.996
Data Source:  Reactome,STRINGDB
MAG
Tchem
Novelty:  0.00085621
Score:  0.991
Data Source:  Reactome,STRINGDB
NGFR
Tclin
Novelty:  0.00072052
Score:  0.987
Data Source:  Reactome,STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.966
Data Source:  Reactome,STRINGDB
LINGO1
Tbio
Novelty:  0.00778085
Score:  0.964
Data Source:  Reactome,STRINGDB
OMG
Tbio
Novelty:  0.00993333
Score:  0.96
Data Source:  Reactome,STRINGDB
Gene Ontology Terms (30)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
physical activity measurement
1
1
1
6.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
physical activity measurement
1
6.5
Find similar targets by:
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
reticulon 4 receptor
VGNC:6015
458663
Macaque
reticulon 4 receptor
694382
Mouse
MGI:2136886
65079
Rat
RGD:620810
113912
Horse
reticulon 4 receptor
VGNC:22618
100051312
Species
Name
OMA
EggNOG
Inparanoid
Chimp
reticulon 4 receptor
Macaque
reticulon 4 receptor
Mouse
Rat
Horse
reticulon 4 receptor
Publication Statistics
PubMed Score 560.30
PubMed score by year
PubTator Score 167.99
PubTator score by year