Tbio FAM129A Protein Niban

Protein Summary

Description

Regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 and RPS6KB1. May be involved in the endoplasmic reticulum stress response (By similarity). This gene encodes a member of the family with sequence similarity 129 protein family. This gene is highly expressed in several cancer cells and may serve as a prognostic marker for certain cancers. The encoded protein may play a role in regulating p53-mediated apoptosis. [provided by RefSeq, Sep 2016]

Uniprot Accession IDs

• Q9BZQ8
• Q2TTR2
• Q5TEM8
• Q8TEI5
• Q9H593
• Q9H9Y8
• Q9HCB9

Gene Name

• FAM129A

Ensembl ID

• ENST00000367511
• ENSP00000356481
• ENSG00000135842

Symbol

• C1orf24
• NIBAN
• GIG39
• NIBAN
• C1orf24

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.94
kinase perturbation	0.91
PubMedID	0.86
transcription factor binding site profile	0.85
transcription factor perturbation	0.8

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.66   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 187   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.66   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0