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Tbio
FAM129A
Protein Niban

Protein Summary
Description
Regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 and RPS6KB1. May be involved in the endoplasmic reticulum stress response (By similarity). This gene encodes a member of the family with sequence similarity 129 protein family. This gene is highly expressed in several cancer cells and may serve as a prognostic marker for certain cancers. The encoded protein may play a role in regulating p53-mediated apoptosis. [provided by RefSeq, Sep 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367511
  • ENSP00000356481
  • ENSG00000135842

Symbol
  • C1orf24
  • NIBAN
  • GIG39
  • NIBAN
  • C1orf24
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.94
kinase perturbation
0.91
PubMedID
0.86
transcription factor binding site profile
0.85
transcription factor perturbation
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.96   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.96   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
1
2
59.8
glomerular filtration rate
1
1
2
37.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
59.8
glomerular filtration rate
2
37.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 129 member A
VGNC:6803
744090
Macaque
family with sequence similarity 129 member A
714427
Mouse
MGI:2137237
63913
Rat
RGD:71088
63912
Dog
family with sequence similarity 129 member A
VGNC:40589
480041
Species
Name
OMA
EggNOG
Inparanoid
Chimp
family with sequence similarity 129 member A
Macaque
family with sequence similarity 129 member A
Mouse
Rat
Dog
family with sequence similarity 129 member A
Gene Ontology Terms (9)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (23)
1 – 10 of 23
CDC5L
Tbio
Family: TF
Novelty: 0.00663599
Score: 0.98
Data Source: STRINGDB
STT3A
Tbio
Family: Enzyme
Novelty: 0.01063504
Score: 0.643
Data Source: STRINGDB
AKT1
Tchem
Family: Kinase
Novelty: 0.00003185
Score: 0.611
Data Source: STRINGDB
SLC29A3
Tbio
Family: Transporter
Novelty: 0.01133239
Score: 0.587
Data Source: STRINGDB
UTP15
Tbio
Novelty: 0.08174586
Score: 0.544
Data Source: STRINGDB
CLMN
Tbio
Novelty: 0.0822701
Score: 0.537
Data Source: STRINGDB
LRRC55
Tbio
Family: IC
Novelty: 0.25121277
Score: 0.529
Data Source: STRINGDB
ZBTB2
Tbio
Family: TF
Novelty: 0.12299559
Score: 0.528
Data Source: STRINGDB
B3GALT1
Tbio
Family: Enzyme
Novelty: 0.14518755
Score: 0.516
Data Source: STRINGDB
ZNF777
Tdark
Family: TF
Novelty: 1.20195224
Score: 0.51
Data Source: STRINGDB
Publication Statistics
PubMed Score  22.96

PubMed score by year
PubTator Score  8.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer