Tchem CHIA Acidic mammalian chitinase

Protein Summary

Description

Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding. The protein encoded by this gene degrades chitin, which is found in the cell wall of most fungi as well as in arthropods and some nematodes. The encoded protein can also stimulate interleukin 13 expression, and variations in this gene can lead to asthma susceptibility. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Uniprot Accession IDs

• Q9BZP6
• Q32W79
• Q32W80
• Q3B866
• Q5U5Z5
• Q5VUV4
• Q86UD8
• Q9ULY3
• Q9ULY4
• AMCase

Gene Name

• CHIA

Ensembl ID

• ENST00000343320
• ENSP00000341828
• ENSG00000134216
• ENST00000353665
• ENSP00000338970
• ENST00000369740
• ENSP00000358755
• ENST00000430615
• ENSP00000391132
• ENST00000451398
• ENSP00000390476
• ENST00000483391
• ENSP00000436946

Symbol

• CHIT2
• AMCASE
• TSA1902

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
biological process	0.6
cell line	0.56
biological term	0.51
tissue	0.51

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 717.33   (req: < 5)

Gene RIFs: 28   (req: <= 3)

Antibodies: 215   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 717.33   (req: >= 5)

Gene RIFs: 28   (req: > 3)

Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 72

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0