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Tchem
CHIA
Acidic mammalian chitinase

Protein Summary
Description
Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding. The protein encoded by this gene degrades chitin, which is found in the cell wall of most fungi as well as in arthropods and some nematodes. The encoded protein can also stimulate interleukin 13 expression, and variations in this gene can lead to asthma susceptibility. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343320
  • ENSP00000341828
  • ENSG00000134216
  • ENST00000353665
  • ENSP00000338970
  • ENST00000369740
  • ENSP00000358755
  • ENST00000430615
  • ENSP00000391132
  • ENST00000451398
  • ENSP00000390476
  • ENST00000483391
  • ENSP00000436946

Symbol
  • CHIT2
  • AMCASE
  • TSA1902
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
biological process
0.6
cell line
0.56
biological term
0.51
tissue
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 588.77   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 215   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 588.77   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Digestion (R-HSA-8935690)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Digestion
Reactome
Digestion and absorption
Reactome
Digestion of dietary carbohydrate
Name
Explore in Pharos
Explore in Source
Digestion
Digestion and absorption
Digestion of dietary carbohydrate
Gene Ontology Terms (14)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (50)
1 – 10 of 50
MINDY1
Tbio
Novelty: 0.54545455
p_int: 0.997908613
p_ni: 0.002091355
p_wrong: 3.2e-8
Score: 0.217
Data Source: BioPlex,STRINGDB
UBR4
Tbio
Family: Enzyme
Novelty: 0.05991158
p_int: 0.986163988
p_ni: 0.013836012
Score: 0.512
Data Source: BioPlex,STRINGDB
GNAL
Tbio
Novelty: 0.0277957
p_int: 0.9528813
p_ni: 0.006099116
p_wrong: 0.041019584
Score: 0.228
Data Source: BioPlex,STRINGDB
TPP2
Tchem
Family: Enzyme
Novelty: 0.01052968
p_int: 0.921669462
p_ni: 0.059019866
p_wrong: 0.019310672
Score: 0.215
Data Source: BioPlex,STRINGDB
TUBA4A
Tchem
Novelty: 0.02626744
p_int: 0.919552045
p_ni: 0.080447955
Score: 0.176
Data Source: BioPlex,STRINGDB
GNB2
Tbio
Novelty: 0.20536996
p_int: 0.856781484
p_ni: 0.143218492
p_wrong: 2.4e-8
Data Source: BioPlex
MOCOS
Tbio
Family: Enzyme
Novelty: 0.08382676
p_int: 0.849302674
p_ni: 0.117952426
p_wrong: 0.0327449
Data Source: BioPlex
RUFY3
Tdark
Novelty: 0.45584046
p_int: 0.838710134
p_ni: 0.161289866
p_wrong: 1e-9
Score: 0.151
Data Source: BioPlex,STRINGDB
SLC2A8
Tbio
Family: Transporter
Novelty: 0.02642686
p_int: 0.82592908
p_ni: 0.060450209
p_wrong: 0.113620711
Score: 0.157
Data Source: BioPlex,STRINGDB
BIRC6
Tbio
Novelty: 0.01472975
p_int: 0.806423778
p_ni: 0.193576222
Score: 0.161
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  588.77

PubMed score by year
PubTator Score  258.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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