Tbio ULBP1 UL16-binding protein 1

Protein Summary

Description

Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. The protein encoded by this gene is a ligand of natural killer group 2, member D (NKG2D), an immune system-activating receptor on NK cells and T-cells. Binding of the encoded ligand to NKG2D leads to activation of several signal transduction pathways, including those of JAK2, STAT5, ERK and PI3K kinase/Akt. Also, in cytomegalovirus-infected cells, this ligand binds the UL16 glycoprotein and is prevented from activating the immune system. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

Uniprot Accession IDs

• Q9BZM6
• Q5VY81
• Q8IZW3
• Q8IZX6

Gene Name

• ULBP1

Ensembl ID

• ENST00000229708
• ENSP00000229708
• ENSG00000111981

Symbol

• N2DL1
• RAET1I
• N2DL-1
• RAET1I
• NKG2DL1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.93
tissue sample	0.79
histone modification site profile	0.76
cell type or tissue	0.61
gene perturbation	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.62   (req: < 5)

Gene RIFs: 24   (req: <= 3)

Antibodies: 242   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.62   (req: >= 5)

Gene RIFs: 24   (req: > 3)

Antibodies: 242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0