ULBP2
UL16-binding protein 2
Protein Summary
Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. This gene encodes a major histocompatibility complex (MHC) class I-related molecule that binds to the NKG2D receptor on natural killer (NK) cells to trigger release of multiple cytokines and chemokines that in turn contribute to the recruitment and activation of NK cells. The encoded protein undergoes further processing to generate the mature protein that is either anchored to membrane via a glycosylphosphatidylinositol moiety, or secreted. Many malignant cells secrete the encoded protein to evade immunosurveillance by NK cells. This gene is located in a cluster of multiple MHC class I-related genes on chromosome 6. [provided by RefSeq, Jul 2015]
- ENST00000367351
- ENSP00000356320
- ENSG00000131015
- N2DL2
- RAET1H
- N2DL2
- RAET1H
- RAET1L
- NKG2DL2
- ALCAN-alpha
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
small molecule perturbation | 0.7 | ||
transcription factor perturbation | 0.68 | ||
tissue sample | 0.64 | ||
cellular component | 0.54 | ||
cell line | 0.53 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 51.17 (req: < 5)
Gene RIFs: 39 (req: <= 3)
Antibodies: 220 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 51.17 (req: >= 5)
Gene RIFs: 39 (req: > 3)
Antibodies: 220 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (136)
RAET1E
Novelty: 0.01859274
p_int: 0.998345178
p_ni: 0.001654817
p_wrong: 5e-9
Score: 0.279
Data Source: BioPlex,STRINGDB
GJB7
Novelty: 0.12555147
p_int: 0.996900437
p_ni: 0.003074426
p_wrong: 0.000025137
Data Source: BioPlex
MED21
Family: Enzyme
Novelty: 0.06996616
p_int: 0.995741061
p_ni: 0.00425884
p_wrong: 9.9e-8
Data Source: BioPlex
SLC4A8
Family: Transporter
Novelty: 0.01606111
p_int: 0.978578349
p_ni: 0.02142164
p_wrong: 1.1e-8
Data Source: BioPlex
SLC39A5
Family: Transporter
Novelty: 0.05205571
p_int: 0.977352807
p_ni: 0.022647181
p_wrong: 1.2e-8
Data Source: BioPlex
HOXB5
Family: TF
Novelty: 0.01119871
p_int: 0.973208833
p_ni: 0.026791164
p_wrong: 3e-9
Score: 0.158
Data Source: BioPlex,STRINGDB
ANKRD12
Novelty: 0.13114331
p_int: 0.958984999
p_ni: 0.041014983
p_wrong: 1.8e-8
Score: 0.28
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (4)
Reactome (3)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism of proteins | ||||
Reactome | Post-translational modification: synthesis of GPI-anchored proteins | ||||
Reactome | Post-translational protein modification | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism of proteins | ||||
Post-translational modification: synthesis of GPI-anchored proteins | ||||
Post-translational protein modification | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (1)
Components (6)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations ()
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
2 | 2 | 0 | 1.6 | 79.7 | |||||
1 | 1 | 0 | 1.1 | 5.8 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.6 | 79.7 | |||||
0 | 1.1 | 5.8 | |||||
Find similar targets by:
IDG Resources
Orthologs
Publication Statistics
PubMed Score 51.17
PubMed score by year
PubTator Score 55.07
PubTator score by year
Related Publications
Text Mined References (52)
GeneRif Annotations (39)
Items per page:
0 of 0
PMID | Year | Title |
|---|