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Tbio
ULBP2
UL16-binding protein 2

Protein Summary
Description
Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. This gene encodes a major histocompatibility complex (MHC) class I-related molecule that binds to the NKG2D receptor on natural killer (NK) cells to trigger release of multiple cytokines and chemokines that in turn contribute to the recruitment and activation of NK cells. The encoded protein undergoes further processing to generate the mature protein that is either anchored to membrane via a glycosylphosphatidylinositol moiety, or secreted. Many malignant cells secrete the encoded protein to evade immunosurveillance by NK cells. This gene is located in a cluster of multiple MHC class I-related genes on chromosome 6. [provided by RefSeq, Jul 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367351
  • ENSP00000356320
  • ENSG00000131015

Symbol
  • N2DL2
  • RAET1H
  • N2DL2
  • RAET1H
  • RAET1L
  • NKG2DL2
  • ALCAN-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.7
transcription factor perturbation
0.68
tissue sample
0.64
cellular component
0.54
cell line
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.17   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 220   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.17   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (136)
TNFSF8
Tbio
Novelty:  0.01292216
p_int:  0.999414182
p_ni:  0.000585818
Data Source:  BioPlex
RAET1E
Tbio
Novelty:  0.01859274
p_int:  0.998345178
p_ni:  0.001654817
p_wrong:  5e-9
Score:  0.279
Data Source:  BioPlex,STRINGDB
GJB7
Tbio
Novelty:  0.12555147
p_int:  0.996900437
p_ni:  0.003074426
p_wrong:  0.000025137
Data Source:  BioPlex
TMEM30B
Tbio
Novelty:  0.26735006
p_int:  0.996575735
p_ni:  0.003424265
Data Source:  BioPlex
MED21
Tbio
Family:  Enzyme
Novelty:  0.06996616
p_int:  0.995741061
p_ni:  0.00425884
p_wrong:  9.9e-8
Data Source:  BioPlex
SLC4A8
Tbio
Family:  Transporter
Novelty:  0.01606111
p_int:  0.978578349
p_ni:  0.02142164
p_wrong:  1.1e-8
Data Source:  BioPlex
FCGRT
Tclin
Novelty:  0.00105713
p_int:  0.977824898
p_ni:  0.022175102
Data Source:  BioPlex
SLC39A5
Tbio
Family:  Transporter
Novelty:  0.05205571
p_int:  0.977352807
p_ni:  0.022647181
p_wrong:  1.2e-8
Data Source:  BioPlex
HOXB5
Tbio
Family:  TF
Novelty:  0.01119871
p_int:  0.973208833
p_ni:  0.026791164
p_wrong:  3e-9
Score:  0.158
Data Source:  BioPlex,STRINGDB
ANKRD12
Tbio
Novelty:  0.13114331
p_int:  0.958984999
p_ni:  0.041014983
p_wrong:  1.8e-8
Score:  0.28
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of proteins (R-HSA-392499)

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Find Similar Targets
Items per page:
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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.6
79.7
1
1
0
1.1
5.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.6
79.7
0
1.1
5.8
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 51.17
PubMed score by year
PubTator Score 55.07
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title