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Tchem
PLA2G2F
Group IIF secretory phospholipase A2

Protein Summary
Description
May play a role in lipid mediator production in inflammatory conditions, by providing arachidonic acid to downstream cyclooxygenases and lipoxygenases (By similarity). Phospholipase A2, which catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (PubMed:11112443). Hydrolyzes phosphatidylethanolamine more efficiently than phosphatidylcholine, with only a modest preference for arachidonic acid versus linoelic acid at the sn-2 position. Comparable activity toward 1-palmitoyl-2-oleoyl-phosphatidylserine vesicles to that toward 1-palmitoyl-2-oleoyl-phosphatidylglycerol (By similarity). Hydrolyzes phosphatidylglycerol versus phosphatidylcholine with a 15-fold preference (PubMed:11112443).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375102
  • ENSP00000364243
  • ENSG00000158786

Symbol
  • GIIFsPLA2
  • sPLA2-IIF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
0.95
pathway
0.59
microRNA
0.58
cell type or tissue
0.49
hub protein
0.49


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.76   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 2   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.76   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 2   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phospholipase A2 group IIF
VGNC:9880
748868
Mouse
MGI:1349661
26971
Rat
RGD:1597305
690388
Dog
phospholipase A2 group IIF
VGNC:44624
487397
Horse
phospholipase A2 group IIF
VGNC:21511
100071833
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phospholipase A2 group IIF
Mouse
Rat
Dog
phospholipase A2 group IIF
Horse
phospholipase A2 group IIF
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BZM2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (22)
Acyl chain remodelling of PC (R-HSA-1482788)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acyl chain remodelling of PC
Reactome
Acyl chain remodelling of PE
Reactome
Acyl chain remodelling of PG
Reactome
Acyl chain remodelling of PI
Reactome
Acyl chain remodelling of PS
Name
Explore in Pharos
Explore in Source
Acyl chain remodelling of PC
Acyl chain remodelling of PE
Acyl chain remodelling of PG
Acyl chain remodelling of PI
Acyl chain remodelling of PS
Gene Ontology Terms (20)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (65)
1 – 10 of 65
PTGS2
Tclin
Family: Enzyme
Novelty: 0.00007089
Score: 0.809
Data Source: STRINGDB
PNPLA7
Tdark
Family: Enzyme
Novelty: 0.11025485
Score: 0.803
Data Source: STRINGDB
PLD1
Tchem
Family: Enzyme
Novelty: 0.00608142
Score: 0.8
Data Source: STRINGDB
ALOX15B
Tchem
Family: Enzyme
Novelty: 0.01578108
Score: 0.776
Data Source: STRINGDB
PTGS1
Tclin
Family: Enzyme
Novelty: 0.00043214
Score: 0.776
Data Source: STRINGDB
PNPLA6
Tbio
Family: Enzyme
Novelty: 0.00295195
Score: 0.753
Data Source: STRINGDB
CYP2J2
Tchem
Novelty: 0.00534181
Score: 0.75
Data Source: STRINGDB
ALOX15
Tchem
Family: Enzyme
Novelty: 0.00184734
Score: 0.746
Data Source: STRINGDB
PLA2G16
Tbio
Novelty: 0.02310886
Score: 0.727
Data Source: STRINGDB
PLA2G7
Tchem
Family: Enzyme
Novelty: 0.00270949
Score: 0.726
Data Source: STRINGDB
Publication Statistics
PubMed Score  2.76

PubMed score by year
PubTator Score  3.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer