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Tchem
PRKD2
Serine/threonine-protein kinase D2

Protein Summary
Description
Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion (PubMed:15604256, PubMed:14743217, PubMed:17077180, PubMed:16928771, PubMed:17962809, PubMed:17951978, PubMed:18262756, PubMed:19192391, PubMed:19001381, PubMed:23503467, PubMed:28428613). May potentiate mitogenesis induced by the neuropeptide bombesin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression (By similarity). In response to oxidative stress, is ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291281
  • ENSP00000291281
  • ENSG00000105287
  • ENST00000433867
  • ENSP00000393978
  • ENST00000595515
  • ENSP00000470804
  • ENST00000600194
  • ENSP00000472744
  • ENST00000601806
  • ENSP00000469106

Symbol
  • PKD2
  • PKD2
  • HSPC187
  • nPKC-D2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
protein domain
1
drug perturbation
0.99
disease perturbation
0.97
kinase
0.96


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.86   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 526   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.86   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 526   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 42
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
1
2
79
2
2
0
1.2
75
2
1
0
1.3
69.4
1
1
0
1.4
47.7
eosinophil count
1
1
1
16.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
79
0
1.2
75
0
1.3
69.4
0
1.4
47.7
eosinophil count
1
16.4
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein kinase D2
VGNC:2280
468929
Mouse
MGI:2141917
101540
Rat
RGD:1308054
292658
Dog
protein kinase D2
VGNC:44987
484427
Cow
protein kinase D2
VGNC:33337
782793
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein kinase D2
Mouse
Rat
Dog
protein kinase D2
Cow
protein kinase D2
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9BZL6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (17)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Sphingolipid de novo biosynthesis
Reactome
Sphingolipid metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Sphingolipid de novo biosynthesis
Sphingolipid metabolism
Gene Ontology Terms (48)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (54)
1 – 10 of 54
SLC9A3R2
Tbio
Family: Transporter
Novelty: 0.01401705
p_int: 0.999206623
p_ni: 0.000793375
p_wrong: 2e-9
Data Source: BioPlex
RFFL
Tbio
Family: Enzyme
Novelty: 0.06621524
p_int: 0.998943069
p_ni: 0.001056902
p_wrong: 2.9e-8
Score: 0.28
Data Source: BioPlex,STRINGDB
PHYHIP
Tdark
Family: Enzyme
Novelty: 0.25773185
p_int: 0.998900958
p_ni: 0.001099042
Score: 0.226
Data Source: BioPlex,STRINGDB
PLA2G10
Tchem
Family: Enzyme
Novelty: 0.00289317
p_int: 0.996699371
p_ni: 0.003300629
Data Source: BioPlex
TSC22D4
Tbio
Family: TF
Novelty: 0.25451456
p_int: 0.996435265
p_ni: 0.003551973
p_wrong: 0.000012762
Score: 0.184
Data Source: BioPlex,STRINGDB
IL13RA2
Tbio
Novelty: 0.03465642
p_int: 0.990429284
p_ni: 0.00955284
p_wrong: 0.000017876
Data Source: BioPlex
ARPC5
Tbio
Novelty: 0.03434234
p_int: 0.984939897
p_ni: 0.015017154
p_wrong: 0.000042949
Score: 0.183
Data Source: BioPlex,STRINGDB
ST8SIA4
Tbio
Family: Enzyme
Novelty: 0.00338436
p_int: 0.981689551
p_ni: 0.018088501
p_wrong: 0.000221948
Data Source: BioPlex
SKP2
Tbio
Family: Enzyme
Novelty: 0.00182658
p_int: 0.974881781
p_ni: 0.025101397
p_wrong: 0.000016821
Data Source: BioPlex
TPSB2
Tbio
Family: Enzyme
Novelty: 0.00757397
p_int: 0.974540457
p_ni: 0.025345187
p_wrong: 0.000114357
Data Source: BioPlex
Publication Statistics
PubMed Score  26.86

PubMed score by year
PubTator Score  24.56

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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