Tdark PPP1R12C Protein phosphatase 1 regulatory subunit 12C

Protein Summary

Description

Regulates myosin phosphatase activity. The gene encodes a subunit of myosin phosphatase. The encoded protein regulates the catalytic activity of protein phosphatase 1 delta and assembly of the actin cytoskeleton. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]

Uniprot Accession IDs

• Q9BZL4
• B4DME2
• Q59FK8
• Q6ZPD1
• Q7L8F7
• Q96HW1
• Q9H5H5
• Q9NT00

Gene Name

• PPP1R12C

Ensembl ID

• ENST00000263433
• ENSP00000263433
• ENSG00000125503
• ENST00000435544
• ENSP00000387833

Symbol

• LENG3
• MBS85
• p84
• p85
• AAVS1
• LENG3
• MBS85

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.75
transcription factor	0.69
transcription factor binding site profile	0.67
histone modification site profile	0.64
tissue	0.51

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 298.23   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 50   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 298.23   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 50   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0