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Tbio
UBL5
Ubiquitin-like protein 5

Protein Summary
Description
This gene encodes a member of a group of proteins similar to ubiquitin. The encoded protein is not thought to degrade proteins like ubiquitin but to affect their function through being bound to target proteins by an isopeptide bond. The gene product has been studied as a link to predisposition to obesity based on its expression in Psammomys obesus, the fat sand rat, which is an animal model for obesity studies. Variation in this gene was found to be significantly associated with some metabolic traits (PMID: 15331561) but not associated with childhood obesity (PMID: 19189687). Pseudogenes of this gene are located on chromosomes 3, 5 and 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358666
  • ENSP00000351492
  • ENSG00000198258
  • ENST00000586895
  • ENSP00000468656
  • ENST00000590068
  • ENSP00000466910

Symbol
  • HUB1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
disease perturbation
0.87
interacting protein
0.79
virus perturbation
0.68
kinase perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.96   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 111   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.96   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sleep duration
1
1
1
4.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sleep duration
1
4.4
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (115)
1 – 10 of 115
SART1
Tbio
Novelty: 0.00835627
Score: 0.996
Data Source: STRINGDB
NEDD8
Tbio
Novelty: 0.00305343
Score: 0.975
Data Source: STRINGDB
UBL3
Tbio
Novelty: 0.12397801
Score: 0.945
Data Source: STRINGDB
RBM25
Tbio
Novelty: 0.05557892
Score: 0.87
Data Source: STRINGDB
SNRPG
Tbio
Novelty: 0.1684808
Score: 0.866
Data Source: STRINGDB
UBE2N
Tbio
Novelty: 0.00620946
Score: 0.865
Data Source: STRINGDB
PRPF8
Tbio
Novelty: 0.01717158
Score: 0.862
Data Source: STRINGDB
CAB39
Tbio
Novelty: 0.01592402
Score: 0.835
Data Source: STRINGDB
LSM5
Tbio
Novelty: 0.12669584
Score: 0.827
Data Source: STRINGDB
CDC40
Tbio
Novelty: 0.03139044
Score: 0.813
Data Source: STRINGDB
Publication Statistics
PubMed Score  14.96

PubMed score by year
PubTator Score  278.05

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer