You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
SLC25A39
Solute carrier family 25 member 39

Protein Summary
Description
Required for normal heme biosynthesis. This gene encodes a member of the SLC25 transporter or mitochondrial carrier family of proteins. Members of this family are encoded by the nuclear genome while their protein products are usually embedded in the inner mitochondrial membrane and exhibit wide-ranging substrate specificity. Although the encoded protein is currently considered an orphan transporter, this protein is related to other carriers known to transport amino acids. This protein may play a role in iron homeostasis. [provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000225308
  • ENSP00000225308
  • ENSG00000013306
  • ENST00000377095
  • ENSP00000366299
  • ENST00000590194
  • ENSP00000467681

Symbol
  • CGI69
  • CGI-69
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
disease perturbation
0.9
transcription factor binding site profile
0.82
small molecule perturbation
0.81
histone modification site profile
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.38   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 38   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.38   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 38   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (39)
1 – 10 of 39
HSPD1
Tbio
Novelty: 0.00018924
p_int: 0.999902644
p_ni: 2.75e-7
p_wrong: 0.000097081
Score: 0.275
Data Source: BioPlex,STRINGDB
RUNDC3A
Tdark
Novelty: 0.23296904
Score: 0.81
Data Source: STRINGDB
TMEM14C
Tdark
Novelty: 0.10707234
Score: 0.737
Data Source: STRINGDB
IBA57
Tbio
Family: Enzyme
Novelty: 0.06327415
Score: 0.668
Data Source: STRINGDB
GRN
Tbio
Novelty: 0.00096395
Score: 0.653
Data Source: STRINGDB
ISCA1
Tbio
Novelty: 0.01288069
Score: 0.625
Data Source: STRINGDB
ALAS2
Tbio
Family: Enzyme
Novelty: 0.00491418
Score: 0.576
Data Source: STRINGDB
SLC25A35
Tdark
Family: Transporter
Novelty: 1.19834062
Score: 0.574
Data Source: STRINGDB
SLC22A4
Tbio
Family: Transporter
Novelty: 0.00432387
Score: 0.55
Data Source: STRINGDB
ABCB7
Tbio
Family: Transporter
Novelty: 0.00985796
Score: 0.535
Data Source: STRINGDB
Publication Statistics
PubMed Score  5.38

PubMed score by year
PubTator Score  2.41

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer