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Tbio
TPSD1
Tryptase delta

Protein Summary
Description
Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. Although this gene may be an exception, most of the tryptase genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. Tryptases have been implicated as mediators i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000211076
  • ENSP00000211076
  • ENSG00000095917

Symbol
  • MCP7L1
  • MMCP-7L
  • MCP7-LIKE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.78
tissue sample
0.77
protein domain
0.58
cell line
0.49
cellular component
0.42


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 97   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
4
4
90.4
self reported educational attainment
1
1
1
73.3
neutrophil count
2
2
2
71.5
myeloid white cell count
1
1
1
70
leukocyte count
1
1
1
62.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
90.4
self reported educational attainment
1
73.3
neutrophil count
2
71.5
myeloid white cell count
1
70
leukocyte count
1
62.1
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Opossum
tryptase alpha/beta-1-like
100022090
Species
Name
OMA
EggNOG
Inparanoid
Opossum
tryptase alpha/beta-1-like
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BZJ3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (4)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (4)
1 – 4 of 4
CPA3
Tchem
Family:  Enzyme
Novelty:  0.01537101
Score:  0.649
Data Source:  STRINGDB
CPA4
Tchem
Family:  Enzyme
Novelty:  0.01439845
Score:  0.433
Data Source:  STRINGDB
FAM234A
Tbio
Novelty:  0.15314928
Score:  0.42
Data Source:  STRINGDB
TMEM8A
Tdark
Novelty:  0.15724279
Score:  0.408
Data Source:  STRINGDB
Publication Statistics
PubMed Score  11.00

PubMed score by year
PubTator Score  167.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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