CRNKL1
Crooked neck-like protein 1
Protein Summary
Involved in pre-mRNA splicing process. The crooked neck (crn) gene of Drosophila is essential for embryogenesis and is thought to be involved in cell cycle progression and pre-mRNA splicing. A protein encoded by this human locus has been found to localize to pre-mRNA splicing complexes in the nucleus and is necessary for pre-mRNA splicing. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2013]
- ENST00000377340
- ENSP00000366557
- ENSG00000101343
- ENST00000496549
- ENSP00000428436
- ENST00000536226
- ENSP00000440733
- CRN
- CLF
- CRN
- Clf1
- HCRN
- SYF3
- MSTP021
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.95 | ||
transcription factor perturbation | 0.68 | ||
cellular component | 0.61 | ||
co-expressed gene | 0.61 | ||
cell type or tissue | 0.59 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14.07 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 58 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14.07 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 58 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0