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Tbio
CRNKL1
Crooked neck-like protein 1

Protein Summary
Description
Involved in pre-mRNA splicing process. The crooked neck (crn) gene of Drosophila is essential for embryogenesis and is thought to be involved in cell cycle progression and pre-mRNA splicing. A protein encoded by this human locus has been found to localize to pre-mRNA splicing complexes in the nucleus and is necessary for pre-mRNA splicing. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377340
  • ENSP00000366557
  • ENSG00000101343
  • ENST00000496549
  • ENSP00000428436
  • ENST00000536226
  • ENSP00000440733

Symbol
  • CRN
  • CLF
  • CRN
  • Clf1
  • HCRN
  • SYF3
  • MSTP021
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
transcription factor perturbation
0.68
cellular component
0.61
co-expressed gene
0.61
cell type or tissue
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.02   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 58   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.02   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 58   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (309)
CCDC12
Tdark
Novelty:  0.52297992
p_int:  0.999996612
p_ni:  0.000003388
Score:  0.868
Data Source:  BioPlex,STRINGDB
USB1
Tbio
Family:  Enzyme
Novelty:  0.01677996
p_int:  0.999954824
p_ni:  0.000045176
Score:  0.588
Data Source:  BioPlex,STRINGDB
SYF2
Tbio
Novelty:  0.06114903
p_int:  0.999849304
p_ni:  0.000150696
Score:  0.999
Data Source:  BioPlex,STRINGDB
BCAS2
Tbio
Novelty:  0.05425016
p_int:  0.999834432
p_ni:  0.000165567
p_wrong:  1e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
SNRPE
Tbio
Novelty:  0.02033423
p_int:  0.999677425
p_ni:  0.000322574
Score:  0.997
Data Source:  BioPlex,STRINGDB
SNW1
Tbio
Novelty:  0.01423797
p_int:  0.999669548
p_ni:  0.000330452
Score:  0.999
Data Source:  BioPlex,STRINGDB
KIAA1143
Tdark
Novelty:  3.96985921
p_int:  0.999319662
p_ni:  0.000680338
Score:  0.159
Data Source:  BioPlex,STRINGDB
TSSC4
Tdark
Novelty:  0.17064786
p_int:  0.999287462
p_ni:  0.000712538
Score:  0.535
Data Source:  BioPlex,STRINGDB
DVL3
Tbio
Novelty:  0.01606014
p_int:  0.999251739
p_ni:  0.000748261
Score:  0.55
Data Source:  BioPlex,STRINGDB
ELAVL2
Tbio
Novelty:  0.00370708
p_int:  0.999059587
p_ni:  0.000940413
Score:  0.91
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
4
4
84.3
neutrophil percentage of leukocytes
1
1
1
56.2
lymphocyte percentage of leukocytes
1
1
1
44.2
appendicular lean mass
1
1
1
33.1
sex hormone-binding globulin measurement
2
1
2
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
4
84.3
neutrophil percentage of leukocytes
1
56.2
lymphocyte percentage of leukocytes
1
44.2
appendicular lean mass
1
33.1
sex hormone-binding globulin measurement
2
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
crooked neck pre-mRNA splicing factor 1
VGNC:6084
458125
Macaque
crooked neck pre-mRNA splicing factor 1
699931
Mouse
MGI:1914127
66877
Rat
RGD:7696302
102548514
Dog
crooked neck pre-mRNA splicing factor 1
VGNC:39625
477137
Species
Name
OMA
EggNOG
Inparanoid
Chimp
crooked neck pre-mRNA splicing factor 1
Macaque
crooked neck pre-mRNA splicing factor 1
Mouse
Rat
Dog
crooked neck pre-mRNA splicing factor 1
Publication Statistics
PubMed Score 11.02
PubMed score by year
PubTator Score 104.37
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title