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Tbio
CRNKL1
Crooked neck-like protein 1

Protein Summary
Description
Involved in pre-mRNA splicing process. The crooked neck (crn) gene of Drosophila is essential for embryogenesis and is thought to be involved in cell cycle progression and pre-mRNA splicing. A protein encoded by this human locus has been found to localize to pre-mRNA splicing complexes in the nucleus and is necessary for pre-mRNA splicing. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377340
  • ENSP00000366557
  • ENSG00000101343
  • ENST00000496549
  • ENSP00000428436
  • ENST00000536226
  • ENSP00000440733

Symbol
  • CRN
  • CLF
  • CRN
  • Clf1
  • HCRN
  • SYF3
  • MSTP021
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
transcription factor perturbation
0.68
cellular component
0.61
co-expressed gene
0.61
cell type or tissue
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.07   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 58   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.07   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 58   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0