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Tbio
IRX2
Iroquois-class homeodomain protein IRX-2

Protein Summary
Description
IRX2 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.[supplied by OMIM, Apr 2004]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302057
  • ENSP00000307006
  • ENSG00000170561
  • ENST00000382611
  • ENSP00000372056

Symbol
  • IRXA2
  • IRXA2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
tissue sample
0.72
virus perturbation
0.72
PubMedID
0.68
kinase perturbation
0.66


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.49   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 167   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.49   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
iroquois homeobox 2
VGNC:4051
471446
Macaque
iroquois homeobox 2
695599
Mouse
MGI:1197526
16372
Rat
RGD:1309834
306657
Dog
iroquois homeobox 2
VGNC:42101
488064
Species
Name
OMA
EggNOG
Inparanoid
Chimp
iroquois homeobox 2
Macaque
iroquois homeobox 2
Mouse
Rat
Dog
iroquois homeobox 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BZI1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (64)
1 – 10 of 64
C5orf38
Tdark
Novelty: 0.02767508
Score: 0.901
Data Source: STRINGDB
AKAP11
Tbio
Family: Enzyme
Novelty: 0.0685826
Score: 0.71
Data Source: STRINGDB
DLX1
Tbio
Family: TF
Novelty: 0.01359424
Score: 0.644
Data Source: STRINGDB
EYA1
Tbio
Novelty: 0.00585286
Score: 0.642
Data Source: STRINGDB
DLX2
Tbio
Family: TF
Novelty: 0.00609908
Score: 0.586
Data Source: STRINGDB
NKX6-1
Tbio
Family: TF
Novelty: 0.00776559
Score: 0.552
Data Source: STRINGDB
HOXC13
Tbio
Family: TF
Novelty: 0.01749797
Score: 0.547
Data Source: STRINGDB
APPL1
Tbio
Novelty: 0.00973424
Score: 0.545
Data Source: STRINGDB
MSX1
Tbio
Family: TF
Novelty: 0.00176212
Score: 0.535
Data Source: STRINGDB
GPC5
Tbio
Novelty: 0.01257358
Score: 0.53
Data Source: STRINGDB
Publication Statistics
PubMed Score  42.49

PubMed score by year
PubTator Score  19.34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer