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Tbio
ACP4
Testicular acid phosphatase

Protein Summary
Description
May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage (PubMed:15219672). May play a role in odontogenesis (PubMed:27843125). Acid phosphatases are enzymes capable of hydrolyzing orthophosphoric acid esters in an acid medium. This gene is up-regulated by androgens and is down-regulated by estrogens in the prostate cancer cell line. This gene exhibits a lower level of expression in testicular cancer tissues than in normal tissues. The protein encoded by this gene has structural similarity to prostatic and lysosomal acid phosphatases. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000270593
  • ENSP00000270593
  • ENSG00000142513

Symbol
  • ACPT
  • ACPT
  • AI1J
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.23   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.23   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
ROGDI
Tbio
Novelty:  0.077277
Score:  0.725
Data Source:  STRINGDB
GRM4
Tchem
Family:  GPCR
Novelty:  0.00380434
Score:  0.708
Data Source:  STRINGDB
CPTP
Tbio
Novelty:  0.06769635
Score:  0.708
Data Source:  STRINGDB
SMYD4
Tbio
Family:  Epigenetic
Novelty:  0.18455037
Score:  0.703
Data Source:  STRINGDB
GRM8
Tchem
Family:  GPCR
Novelty:  0.00827879
Score:  0.689
Data Source:  STRINGDB
LSP1
Tbio
Novelty:  0.00889927
Score:  0.689
Data Source:  STRINGDB
ACOT11
Tbio
Family:  Enzyme
Novelty:  0.0400726
Score:  0.68
Data Source:  STRINGDB
KLK4
Tchem
Family:  Enzyme
Novelty:  0.00019849
Score:  0.676
Data Source:  STRINGDB
GRM7
Tchem
Family:  GPCR
Novelty:  0.00416377
Score:  0.675
Data Source:  STRINGDB
KLK1
Tchem
Family:  Enzyme
Novelty:  0.00190157
Score:  0.643
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate specific antigen measurement
8
6
7
39.1
99.4
9
7
2
1.2
97.6
1
2
0
1.3
84
Gleason score measurement
1
1
1
28.1
cancer aggressiveness measurement
1
1
1
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate specific antigen measurement
7
39.1
99.4
2
1.2
97.6
0
1.3
84
Gleason score measurement
1
28.1
cancer aggressiveness measurement
1
28.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acid phosphatase 4
VGNC:14864
100613812
Macaque
acid phosphatase 4
719401
Mouse
MGI:3644563
100503991
Dog
acid phosphatase 4
VGNC:53522
484357
Horse
acid phosphatase 4 [Source:HGNC Symbol;Acc:HGNC:14376]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acid phosphatase 4
Macaque
acid phosphatase 4
Mouse
Dog
acid phosphatase 4
Horse
acid phosphatase 4 [Source:HGNC Symbol;Acc:HGNC:14376]
Publication Statistics
PubMed Score 70.23
PubMed score by year
PubTator Score 6.75
PubTator score by year
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Related Publications
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PMID
Year
Title